(R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine

Base Information

• Chemical Name: (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine
• CAS No.: 88852-09-9
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 88852-09-9.mol

Synonyms:(R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine

Chemical Property of (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine

There total 1 articles about (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dimethoxybenzylamine (20781-20-8) + (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde (22323-80-4) → (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine (88852-09-9)

Guidance literature:

DOI:10.1002/hlca.19830660732

Reference yield:

N-phthaloylglycine chloride (6780-38-7) + (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine (88852-09-9) → N-<(3S,4S)-cis-1-(2,4-dimethoxybenzyl)-4-<(R)-2,2-dimethyl-1,3-dioxalan-4-yl>-2-oxo-3-azetidinyl>phthalimide (86390-73-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1002/hlca.19830660732

Reference yield:

(R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine (88852-09-9) → (3S,4S)-3-(benzyloxycarboxamido)-1-(2,4-dimethoxybenzyl)-4-formyl-2-azetidinone (86299-41-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent Chromat_. / Et₃N / CH₂Cl₂ / 0 °C

2: 96 percent / NH₂NHCH₃ / CH₂Cl₂ / 48 h / 25 °C

3: butylene oxide / CH₂Cl₂

4: TsOH / tetrahydrofuran; H₂O / 80 °C

5: NaIO₄ / methanol

With tetrahydrofuran; sodium periodate; toluene-4-sulfonic acid; triethylamine; methylhydrazine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1002/hlca.19830660732

upstream raw materials:

2,4-Dimethoxybenzylamine

(4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

Downstream raw materials:

N-<(3S,4S)-cis-1-(2,4-dimethoxybenzyl)-4-<(R)-2,2-dimethyl-1,3-dioxalan-4-yl>-2-oxo-3-azetidinyl>phthalimide

(3S,4S)-3-(benzyloxycarboxamido)-1-(2,4-dimethoxybenzyl)-4-formyl-2-azetidinone

(3S,4S)-3-amino-1-(2,4-dimethoxybenzyl)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)azetidin-2-one

benzyl ((2S,3S)-1-(2,4-dimethoxybenzyl)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-oxoazetidin-3-yl)-carbamate