2,3-Bis(benzyloxy)benzoyl chloride

Base Information

• Chemical Name: 2,3-Bis(benzyloxy)benzoyl chloride
• CAS No.: 69146-58-3
• Molecular Formula: C₂₁H₁₇ClO₃
• Molecular Weight: 352.817
• DSSTox Substance ID: DTXSID201282748
• Nikkaji Number: J741.137E
• Mol file: 69146-58-3.mol

Synonyms:2,3-bis(phenylmethoxy)benzoyl Chloride;SCHEMBL6476026;2,3-dibenzyloxybenzoyl chloride;DTXSID201282748;2,3-Bis(benzyloxy)benzoyl chloride;69146-58-3

Chemical Property of 2,3-Bis(benzyloxy)benzoyl chloride

Chemical Property:

• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 352.0866221
• Heavy Atom Count: 25
• Complexity: 402

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2OCC3=CC=CC=C3)C(=O)Cl

Technology Process of 2,3-Bis(benzyloxy)benzoyl chloride

There total 11 articles about 2,3-Bis(benzyloxy)benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

2,3-dibenzyloxybenzoic acid (74272-78-9) → 2,3-bis(benzyloxy)benzoyl chloride (69146-58-3)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

DOI:10.1002/chem.200801552

Reference yield:

2,3-bis(benzyloxy)benzaldehyde (5779-91-9) → 2,3-bis(benzyloxy)benzoyl chloride (69146-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaClO₂, H₂NSO₃H / acetone; H₂O / Ambient temperature

2: 94 percent / (COCl)2

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; In water; acetone;

DOI:10.1016/S0040-4039(98)00610-8

Reference yield:

2,3-dihydroxybenzaldehyde (24677-78-9) → 2,3-bis(benzyloxy)benzoyl chloride (69146-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / ethanol

2: 90 percent / NaClO₂, H₂NSO₃H / acetone; H₂O / Ambient temperature

3: 94 percent / (COCl)2

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; potassium carbonate; In ethanol; water; acetone;

DOI:10.1016/S0040-4039(98)00610-8

upstream raw materials:

2,3-dibenzyloxybenzoic acid

2,3-Dihydroxybenzoic acid

benzyl bromide

benzyl 2,3-bis(benzyloxy)benzoate

Downstream raw materials:

Hexa-O-benzylenterochelin

N-<2,3-bis(benzyloxy)benzoyl>-L-alanine

N-<2,3-bis(benzyloxy)benzoyl>-D-alanine

2,3-dibenzyloxybenzoyl-L-serine methyl ester