N,N,2,2-tetramethylpropanethioamide

Base Information

• Chemical Name: N,N,2,2-tetramethylpropanethioamide
• CAS No.: 25530-28-3
• Molecular Formula: C7H15NS
• Molecular Weight: 145.269
• Mol file: 25530-28-3.mol

Synonyms:

Chemical Property of N,N,2,2-tetramethylpropanethioamide

Chemical Property:

• Vapor Pressure: 1.82mmHg at 25°C
• Boiling Point: 166°Cat760mmHg
• Flash Point: 54.2°C
• Density: 0.928g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N,2,2-tetramethylpropanethioamide

There total 5 articles about N,N,2,2-tetramethylpropanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N-dimethylpivalamide (24331-71-3) → N,N,2,2-tetramethylpropanethioamide (25530-28-3)

Guidance literature:

With trichlorothiophosphine; water; In 1,4-dioxane; at 100 - 110 ℃; for 7h;

DOI:10.1134/S1070363208070098

Reference yield:

pivaloyl chloride (3282-30-2) → N,N,2,2-tetramethylpropanethioamide (25530-28-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 25 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide / tetrahydrofuran / 16 h / Heating

With Lawessons reagent; In tetrahydrofuran;

Reference yield:

pivaloyl chloride (3282-30-2) → N,N,2,2-tetramethylpropanethioamide (25530-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: Lawessons reagent / toluene / 100 °C

With Lawessons reagent; triethylamine; In dichloromethane; toluene;

DOI:10.1021/jacs.5b06740

upstream raw materials:

N,N-dimethylpivalamide

O,O-Diethyl hydrogen phosphorodithioate

pivaloyl chloride

Downstream raw materials:

N-Hexyl-N-methylthiopivalamid

N,2,2-trimethyl-N-phenethylpropanethioamide

N-(2-Hydroxy-3-methylbutyl)-N-methylthiopivalamid

N-Athyl-N-methylthiopivalamid