Silane, trimethyl(2-methylphenyl)-

Base Information

• Chemical Name: Silane, trimethyl(2-methylphenyl)-
• CAS No.: 7450-03-5
• Molecular Formula: C10H16Si
• Molecular Weight: 164.323
• Mol file: 7450-03-5.mol

Synonyms:Silane,trimethyl-O-tolyl;o-tolyl-TMS;o-trimethylsilyltoluene;

Chemical Property of Silane, trimethyl(2-methylphenyl)-

Chemical Property:

• PSA: 0.00000
• LogP: 2.54020

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Silane, trimethyl(2-methylphenyl)-

There total 20 articles about Silane, trimethyl(2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloro-trimethyl-silane (75-77-4) + 2-methylphenyl bromide (95-46-5) → (2-methylphenyl)trimethylsilane (7450-03-5)

Guidance literature:

2-methylphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Product distribution / selectivity;

Reference yield: 86.5%

chloro-trimethyl-silane (75-77-4) → (2-methylphenyl)trimethylsilane (7450-03-5)

Guidance literature:

With Na; In toluene;

DOI:10.1021/ja01156a104 DOI:10.1021/ja01152a070 DOI:10.1021/ja01108a009

Reference yield: 84.0%

chloro-trimethyl-silane (75-77-4) + 1-methyl-2-(trifluoromethoxy)benzene (42908-77-0) → (2-methylphenyl)trimethylsilane (7450-03-5)

Guidance literature:

With sodium; In tetrahydrofuran; at 80 ℃; for 24h; chemoselective reaction;

DOI:10.1016/j.tetlet.2008.08.002

upstream raw materials:

ortho-tolylmagnesium bromide

chloro-trimethyl-silane

2-methylchlorobenzene

(2-methylphenyl)lithium

Downstream raw materials:

(2-dibromomethyl-phenyl)-trimethyl-silane

2-(trimethylsilyl)benzoic acid

1-bromomethyl-2-trimethylsilyl-benzene

(2-methylcyclohexyl)trimethylsilane

Refernces

• 1、 Harper, Matthew J.,Emmett, Edward J.,Bower, John F.,Russell, Christopher A.. "Oxidative 1,2-Difunctionalization of Ethylene via Gold-Catalyzed Oxyarylation". supporting information. p. 12386 - 12389. Retrieved 2017/09/22.
• 2、 Ball, Liam T.,Lloyd-Jones, Guy C.,Russell, Christopher A.. "Gold-catalysed oxyarylation of styrenes and mono- and gem-disubstituted olefins facilitated by an iodine(III) oxidant". supporting information; experimental part. p. 2931 - 2937. Retrieved 2012/04/23.