5-methyl-4-phenylfuran-2(5H)-one

Base Information

• Chemical Name: 5-methyl-4-phenylfuran-2(5H)-one
• CAS No.: 74528-46-4
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• DSSTox Substance ID: DTXSID40504592
• Nikkaji Number: J986.943C
• Mol file: 74528-46-4.mol

Synonyms:5-methyl-4-phenylfuran-2(5H)-one;74528-46-4;SCHEMBL3219657;DTXSID40504592;OJWAMZOEVHRNQN-UHFFFAOYSA-N;5-methyl-4-phenyl-2(5H)furanone;4-methyl-3-phenyl-2-buten-1,4-olide

Chemical Property of 5-methyl-4-phenylfuran-2(5H)-one

Chemical Property:

• PSA: 26.30000
• LogP: 2.01530
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 237

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(=CC(=O)O1)C2=CC=CC=C2

Technology Process of 5-methyl-4-phenylfuran-2(5H)-one

There total 28 articles about 5-methyl-4-phenylfuran-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Acetic acid 2-methyl-5-oxo-3-phenyl-tetrahydro-furan-2-yl ester (74528-44-2) → 5-methyl-4-phenylfuran-2(5H)-one (74528-46-4)

Guidance literature:

Heating;

DOI:10.1055/s-1980-29034

Reference yield: 94.0%

4-Oxo-3-phenylpentanoic acid (6049-50-9) → 5-methyl-4-phenylfuran-2(5H)-one (74528-46-4)

Guidance literature:

With PPA (polyphosphoric acid); at 100 ℃; for 2h;

DOI:10.1055/s-1980-29034

Reference yield: 92.0%

(+/-)-tert-butyl penta-2,3-dienoate (1262883-53-3) + benzenediazonium tetrafluoroborate (369-57-3) → 5-methyl-4-phenylfuran-2(5H)-one (74528-46-4)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; In methanol; acetonitrile; at 20 ℃; Reagent/catalyst; Temperature; Irradiation; Inert atmosphere;

DOI:10.1002/adsc.201500525

upstream raw materials:

3-phenylpent-4-enoic acid

4-Oxo-3-phenylpentanoic acid

3-phenyl-4-oxopentanoic acid ethyl ester

1-methylphenacyl (trimethylsilyl)acetate