4-broMo-2-fluoro-5-Methoxy-benzaldehyde

Base Information

• Chemical Name: 4-broMo-2-fluoro-5-Methoxy-benzaldehyde
• CAS No.: 749931-20-2
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Hs Code.: 2913000090
• Mol file: 749931-20-2.mol

Synonyms:4-bromo-2-fluoro-5-methoxy-benzaldehyde;4-bromo-2-fluoro-methoxy-benzaldehyde;

Chemical Property of 4-broMo-2-fluoro-5-Methoxy-benzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 2.40930

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

4-Bromo-2-fluoro-5-methoxybenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-broMo-2-fluoro-5-Methoxy-benzaldehyde

There total 3 articles about 4-broMo-2-fluoro-5-Methoxy-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-fluoro-5-methoxybenzaldehyde (105728-90-3) → 4-bromo-2-fluoro-5-methoxybenzaldehyde (749931-20-2)

Guidance literature:

With bromine; In chloroform; at 20 ℃; for 120h;

Reference yield: 60.0%

bromine (7726-95-6) + 2-fluoro-5-methoxybenzaldehyde (105728-90-3) → 4-bromo-2-fluoro-5-methoxybenzaldehyde (749931-20-2)

Guidance literature:

In chloroform; at 20 ℃; for 120h;

Reference yield: 44.0%

Dichloromethyl methyl ether (4885-02-3) + 2-bromo-4-fluoro-1-methoxybenzene (452-08-4) → 4-bromo-2-fluoro-5-methoxybenzaldehyde (749931-20-2)

Guidance literature:

With titanium tetrachloride; for 1h; Inert atmosphere; Cooling with ice;

upstream raw materials:

bromine

2-fluoro-5-methoxybenzaldehyde

Dichloromethyl methyl ether

2-bromo-4-fluoro-1-methoxybenzene

Downstream raw materials:

4-bromo-2-fluoro-5-methoxybenzoic acid

(4-Bromo-2-fluoro-5-methoxy-phenyl)-methanol

Refernces

• 1、 -. "SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION". Page/Page column 36. . Retrieved 2020/07/31.
• 2、 -. "INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME". Page/Page column 167. . Retrieved 2008/06/13.