trans-2-Fluorocyclohexanol

Base Information

• Chemical Name: trans-2-Fluorocyclohexanol
• CAS No.: 75024-00-9
• Molecular Formula: C6H11FO
• Molecular Weight: 118.151
• European Community (EC) Number: 678-920-2,962-862-2
• Nikkaji Number: J755.444C

Synonyms:trans-2-Fluorocyclohexanol;(1R,2R)-2-fluorocyclohexan-1-ol;656-60-0;75024-00-9;14365-32-3;rel-(1R,2R)-2-Fluorocyclohexanol;trans-2-fluoro-cyclohexanol;C6H11FO;SCHEMBL812613;LMYKFDDTPIOYQV-PHDIDXHHSA-N;AKOS005256392;AKOS015852401;rac-(1R,2R)-2-fluorocyclohexan-1-ol;AS-58831;CS-0101188;EN300-158089;T72787;EN300-1198106

Chemical Property of trans-2-Fluorocyclohexanol

Chemical Property:

• Boiling Point: 60 °C (12 mmHg)
• PSA: 20.23000
• LogP: 1.25940
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 118.079393132
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

trans-2-Fluorocyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C(C1)O)F
• Isomeric SMILES: C1CC[C@H]([C@@H](C1)O)F

Technology Process of trans-2-Fluorocyclohexanol

There total 26 articles about trans-2-Fluorocyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.4%

cyclohexane-1,2-epoxide (286-20-4) → 2-fluoro-cyclohexanol (14365-32-3,20421-48-1,75024-00-9,656-60-0)

Guidance literature:

With potassium hydrogen difluoride; In diethylene glycol; at 176 ℃; for 2h;

DOI:10.1016/j.polymer.2011.10.020

Reference yield: 61.0%

2-fluorocyclohexanone (694-82-6) → (±)-cis-2-fluorocyclohexanol (656-60-0,14365-32-3,20421-48-1,75024-00-9)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/chem.201604940

Reference yield: 60.0%

2-chlorocyclohexanol (1561-86-0) → 2-fluoro-cyclohexanol (14365-32-3,20421-48-1,75024-00-9,656-60-0)

Guidance literature:

With potassium fluoride; In diethylene glycol; at 140 ℃; for 5h;

DOI:10.1002/hlca.19830660819

upstream raw materials:

cyclohexane-1,2-epoxide

cyclohexene

2-chlorocyclohexanol

Copper(I) trifluoromethanethiolate

Downstream raw materials:

2-fluorocyclohexanone

C₁₃H₂₂F₂O₂

trans-2-fluoro-1-methoxycyclohexane

C₁₆H₂₃FN₄O₃

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