Benzamide, 4-hydroxy-N-2-propynyl-

Base Information

Chemical Name:Benzamide, 4-hydroxy-N-2-propynyl-
CAS No.:750624-40-9
Molecular Formula:C10H9NO2
Molecular Weight:175.187
Hs Code.:
DSSTox Substance ID:DTXSID00478144

Synonyms:Benzamide, 4-hydroxy-N-2-propynyl-;750624-40-9;SCHEMBL18364959;DTXSID00478144;AKOS000207151

Suppliers and Price of Benzamide, 4-hydroxy-N-2-propynyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 4-hydroxy-N-2-propynyl-

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:175.063328530
Heavy Atom Count:13
Complexity:220

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CCNC(=O)C1=CC=C(C=C1)O

Technology Process of Benzamide, 4-hydroxy-N-2-propynyl-

There total 6 articles about Benzamide, 4-hydroxy-N-2-propynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2450-71-7
Propargylamine

: 99-96-7
4-hydroxy-benzoic acid

: 750624-40-9
4-hydroxy-N-(prop-2-ynyl)benzamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1002/chem.200601263

Reference yield: 35.0%

: 82225-33-0
4-methoxy-N-(prop-2-yn-1-yl)benzamide

: 750624-40-9
4-hydroxy-N-(prop-2-ynyl)benzamide

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol0489898

Reference yield:

: 100-09-4
4-methoxybenzoic acid

: 750624-40-9
4-hydroxy-N-(prop-2-ynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / DMAP; DCC / CH₂Cl₂ / 10 h / 20 °C

2: 35 percent / BBr₃ / CH₂Cl₂ / 2 h / 20 °C

With dmap; boron tribromide; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/ol0489898