N-(4-Hydroxybutyl)acetamide

Base Information

• Chemical Name: N-(4-Hydroxybutyl)acetamide
• CAS No.: 75694-83-6
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• DSSTox Substance ID: DTXSID40577605
• Wikidata: Q82467662
• Mol file: 75694-83-6.mol

Synonyms:N-(4-Hydroxybutyl)acetamide;75694-83-6;4-acetylaminobutanol;SCHEMBL48871;DTXSID40577605;OLKOIWQNCSVBCU-UHFFFAOYSA-N;MFCD11611963;AKOS006318914;NS-01050

Chemical Property of N-(4-Hydroxybutyl)acetamide

Chemical Property:

• PSA: 52.82000
• LogP: 0.73530
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 83.1

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Hydroxybutyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCCCCO

Technology Process of N-(4-Hydroxybutyl)acetamide

There total 1 articles about N-(4-Hydroxybutyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetylpyrrolidinone (932-17-2) → 2-pyrrolidinon (616-45-5) + N-(4-hydroxybutyl)acetamide (75694-83-6)

Guidance literature:

With trans-[RuH₂((R)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl)((R,R)-1,2-diphenylethylenediamine)]; hydrogen; potassium hexamethylsilazane; In tetrahydrofuran; at 80 ℃; for 16h; under 38002.6 Torr; Autoclave;

DOI:10.1002/anie.201103137

Reference yield: 35.0%

N-(4-hydroxybutyl)acetamide (75694-83-6) → N-acetylpyrrolidinone (932-17-2)

Guidance literature:

With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); N,N'-(3,3'-bis(propyl)methylamine)bis(salicylideneiminato)cobalt(II); 2,6-dimethoxy-p-quinone; In toluene; at 100 ℃; for 18h; under 760.051 Torr;

DOI:10.1002/chem.201202080

Reference yield:

N-(4-hydroxybutyl)acetamide (75694-83-6) + C29H30ClN2O6P (159830-25-8) → [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid 4-acetylamino-butyl ester 4-nitro-benzyl ester

Guidance literature:

In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/ja962465o

upstream raw materials:

N-acetylpyrrolidinone

Downstream raw materials:

N-acetylpyrrolidinone