932-17-2

Basic information

• Product Name: 1-ACETYL-2-PYRROLIDONE
• Synonyms: 1-acetyl-2-pyrrolidinon;1-Acetyl-2-pyrrolidinone;2-Pyrrolidinone, 1-acetyl-;N-Acetyl-2-pyrrolidinone;N-ACETYL-2-PYRROLIDONE;TIMTEC-BB SBB007922;1-ACETYL-2-PYRROLIDONE;1-Acetyl-2-pyrrolidine
• CAS NO: 932-17-2
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 127.14
• EINECS: 213-248-1
• Mol File: 932-17-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 231 °C
• Flash Point: 110.7 °C
• Appearance: /
• Density: 1,15 g/cm3
• Vapor Pressure: 0.0315mmHg at 25°C
• Refractive Index: 1.4810-1.4850
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.34±0.20(Predicted)
• Water Solubility: Slightly soluble in water
• CAS DataBase Reference: 1-ACETYL-2-PYRROLIDONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ACETYL-2-PYRROLIDONE(932-17-2)
• EPA Substance Registry System: 1-ACETYL-2-PYRROLIDONE(932-17-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: UY5717000
• Hazardous Substances Data: 932-17-2(Hazardous Substances Data)

Usage

General Description

1-Acetyl-2-pyrrolidone, also known as AP, is a chemical compound that is commonly used as a solvent and a chemical intermediate in various industries. It is a clear, colorless liquid with a slightly sweet odor and has a high boiling point, making it suitable for use in a wide range of applications. It is often utilized as a solvent for polymers, resins, and other chemicals, and it is also used as a solubilizer and dispersant. In addition, 1-acetyl-2-pyrrolidone is used in the production of pharmaceuticals, agrochemicals, and electronic components. Its versatile properties and low toxicity make it a valuable chemical in many industrial processes.

InChI:InChI=1/C6H9NO2/c1-5(8)7-4-2-3-6(7)9/h2-4H2,1H3

Upstream product

• 616-45-5 2-pyrrolidinon 
• 108-22-5 Isopropenyl acetate 
• 108-24-7 acetic anhydride 
• 2687-91-4 1-ethyl-2-pyrrolidinone 
• 4030-18-6 N-(acetyl)pyrrolidine 
• 692-33-1 N-allylacetamide 
• 201230-82-2 carbon monoxide 
• 3025-96-5 N-Acetyl-4-aminobutyric acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 75694-83-6 N-(4-hydroxybutyl)acetamide 
• 5264-35-7 2-methoxy-1-pyrroline 
• 183208-72-2 N-[4-(1,1,1-trimethylsilyl)-3-butyn-1-yl]acetamide 
• 75-36-5 acetyl chloride 

Downstream Products

• 616-45-5 2-pyrrolidinon 
• 75694-83-6 N-(4-hydroxybutyl)acetamide 
• 1438408-89-9 (E)-3-(4-ethoxybenzylidene)pyrrolidin-2-one 
• 1859-41-2 (E)-3-phenylmethylene-2-pyrrolidinone 
• 1859-52-5 3-Veratryliden-2-pyrrolidon 
• 1859-44-5 3-(2-methoxy-benzylidene)-pyrrolidin-2-one 
• 246181-62-4 1-acetyl-5-fluoro-2-pyrrolidinone 
• 872-32-2 2-methyl-1H-pyrroline 
• 1859-42-3 2-oxo-3-piperonyliden-pyrrolidin 

Relevant articles and documents

New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization

The design and synthesis of a series of new fluorescent coumarin-containing melatonin analogues is presented. The combination of high-binding affinities for human melatonergic receptors (h-MT1R and h-MT2R) and fluorescent properties, derived from the inclusion of melatonin pharmacophoric elements in the coumarin scaffold, yielded suitable candidates for the development of MT1R and MT2R fluorescent probes for imaging in biological media.

Palladium-Catalyzed Hydroamidocarbonylation of Olefins to Imides

Carbonylation reactions allow the efficient synthesis of all kinds of carbonyl-containing compounds. Here, we report a straightforward synthesis of various imides from olefins and CO for the first time. The established hydroamidocarbonylation reaction affords imides in good yields (up to 90%) and with good regioselectivity (up to 99:1) when applying different alkenes and amides. The synthetic potential of the method is highlighted by the synthesis of Aniracetam by intramolecular hydroamidocarbonylation.

Chemoselective palladium-catalyzed oxidation of vinyl ether to acetate using hydrogen peroxide

A practical and environmental-friendly method was developed to convert vinyl ether into acetate by using a palladium complex with phosphine ligand and hydrogen peroxide. The only by-product is water. Chemoselective oxidation of vinyl ether and tert-enamides to form acetate and N-acetyl amide with hydrogen peroxide in the presence of palladium complex having phosphine ligand was developed under mild reaction conditions. This process is environmentally friendly because it uses hydrogen peroxide as a clean oxidant, with water being the only byprocuct.