7,2',4'-Trimethoxyflavone

Base Information

• Chemical Name: 7,2',4'-Trimethoxyflavone
• CAS No.: 7578-51-0
• Molecular Formula: C18H16O5
• Molecular Weight: 312.322
• DSSTox Substance ID: DTXSID50350981
• Nikkaji Number: J1.785.907B
• Wikidata: Q82127058
• Metabolomics Workbench ID: 23140
• Mol file: 7578-51-0.mol

Synonyms:7,2',4'-trimethoxyflavone

Chemical Property of 7,2',4'-Trimethoxyflavone

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 312.09977361
• Heavy Atom Count: 23
• Complexity: 460

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(=O)C=C(O2)C3=C(C=C(C=C3)OC)OC

Technology Process of 7,2',4'-Trimethoxyflavone

There total 12 articles about 7,2',4'-Trimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

7-methoxy-4H-chromen-4-one (5751-52-0) + 2,4-dimethoxyphenylboronic acid (133730-34-4) → 2-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one (7578-51-0)

Guidance literature:

7-methoxy-4H-chromen-4-one; With 1,10-Phenanthroline; oxygen; palladium diacetate; In N,N-dimethyl-formamide; for 0.0833333h;

2,4-dimethoxyphenylboronic acid; In N,N-dimethyl-formamide; at 100 ℃; for 24h; regioselective reaction;

DOI:10.1039/c2cc18150a

Reference yield: 80.0%

2'',4'',4'-trimethoxy-2'-hydroxychalcone → 2-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one (7578-51-0)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 190 ℃; for 0.333333h;

DOI:10.1021/cc100076k

Reference yield: 34.0%

7,2',4'-trimethoxyflavanone (132351-64-5) → 2-(2,4-dimethoxyphenyl)-7-methoxy-4H-chromen-4-one (7578-51-0) + 3-(2,4-Dimethoxy-5-nitro-phenyl)-7-methoxy-chromen-4-one

Guidance literature:

With perchloric acid; thallium(III) nitrate; In methanol; chloroform; at 25 ℃;

DOI:10.1016/S0040-4039(00)88565-2

upstream raw materials:

1,3-di-(2,4-dimethoxyphenyl)-1,3-propanedione

7,2',4'-trimethoxyflavanone

2',4'-dihydroxy-4-acetophenone

1-(2-hydroxy-4-methoxyphenyl)ethanone

Downstream raw materials:

2-(2,4-dimethoxy-phenyl)-7-methoxy-chromen-4-one oxime