4-(2-(1H-imidazol-1-yl)ethoxy)aniline

Base Information

• Chemical Name: 4-(2-(1H-imidazol-1-yl)ethoxy)aniline
• CAS No.: 75912-83-3
• Molecular Formula: C11H13N3O
• Molecular Weight: 203.244
• ChEMBL ID: CHEMBL33689
• DSSTox Substance ID: DTXSID90544049
• Wikidata: Q82421024

Synonyms:75912-83-3;4-(2-Imidazol-1-ylethoxy)aniline;4-(2-Imidazol-1-yl-ethoxy)-phenylamine;4-(2-(1H-imidazol-1-yl)ethoxy)aniline;Benzenamine, 4-[2-(1H-imidazol-1-yl)ethoxy]-;CHEMBL33689;4-[2-(1H-Imidazol-1-yl)ethoxy]aniline;SCHEMBL76839;DTXSID90544049;AFRDTKWHTKFULR-UHFFFAOYSA-N;BDBM50026003;4-[2-(imidazol-1-yl)ethoxy]aniline;AKOS009388622;1-[2-(4-aminophenoxy)ethyl]imidazole;4-[2-(1H-imidazol-1-yl)ethoxy]benzenamine;EN300-58468;A1-05107

Chemical Property of 4-(2-(1H-imidazol-1-yl)ethoxy)aniline

Chemical Property:

• Melting Point: 91-93 °C
• Boiling Point: 453.1±25.0 °C(Predicted)
• PSA: 53.07000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 2.12550
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 203.105862047
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

4-(2-Imidazol-1-ylethoxy)aniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)OCCN2C=CN=C2

Technology Process of 4-(2-(1H-imidazol-1-yl)ethoxy)aniline

There total 12 articles about 4-(2-(1H-imidazol-1-yl)ethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-[2-(diethylamino)ethoxy]aniline (38519-63-0) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → 4-(2-imidazol-1-yl-ethoxy)-phenylamine (75912-83-3)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at -15 - 20 ℃; for 1h;

Reference yield: 82.0%

1-[2-(4-nitro-phenoxy)ethyl]-1H-imidazole (75912-69-5) → 4-(2-imidazol-1-yl-ethoxy)-phenylamine (75912-83-3)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; Reflux;

DOI:10.1021/acsinfecdis.0c00855

Reference yield:

iron (7439-89-6) + 1-[2-(4-nitro-phenoxy)ethyl]-1H-imidazole (75912-69-5) → 4-(2-imidazol-1-yl-ethoxy)-phenylamine (75912-83-3)

Guidance literature:

In hydrogenchloride;

upstream raw materials:

1-[2-(4-nitro-phenoxy)ethyl]-1H-imidazole

1H-imidazole

4-(2-bromoethoxy)phenylamine

4-amino-phenol

Downstream raw materials:

<4-<2-(1H-imidazol-1-yl)ethoxy>phenyl>urea

7-[4-(2-butoxyethoxy)phenyl]-N-[4-[2-(imidazol-1-yl)ethoxy]phenyl]-1-propyl-2,3-dihydro-1-benzazepine-4-carboxamide

1-[2-(4-isothiocyanato-phenoxy)-ethyl]-1H-imidazole

C₂₃H₁₉N₅O₃

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