N-(4-Bromophenyl)methacrylamide

Base Information

• Chemical Name: N-(4-Bromophenyl)methacrylamide
• CAS No.: 7600-35-3
• Molecular Formula: C10H10BrNO
• Molecular Weight: 240.099
• DSSTox Substance ID: DTXSID80599967
• Nikkaji Number: J800.029H
• Wikidata: Q82495931
• Mol file: 7600-35-3.mol

Synonyms:N-(4-BROMOPHENYL)METHACRYLAMIDE;7600-35-3;N-(4-Bromophenyl)-2-methylprop-2-enamide;SCHEMBL8966429;DTXSID80599967;MFCD01069115;AKOS015835619;BS-23670;DB-371112;CS-0455579;A865578

Chemical Property of N-(4-Bromophenyl)methacrylamide

Chemical Property:

• Boiling Point: 365.8±34.0 °C(Predicted)
• PKA: 12.89±0.70(Predicted)
• PSA: 29.10000
• Density: 1.441±0.06 g/cm3(Predicted)
• LogP: 3.03670
• Storage Temp.: Room temperature.
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 238.99458
• Heavy Atom Count: 13
• Complexity: 207

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Bromophenyl)methacrylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)NC1=CC=C(C=C1)Br

Technology Process of N-(4-Bromophenyl)methacrylamide

There total 5 articles about N-(4-Bromophenyl)methacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methyl-N-phenylacrylamide (1611-83-2) → N-(4-bromophenyl)methacrylamide (7600-35-3)

Guidance literature:

With Eosin Y; Selectfluor; In acetonitrile; at 25 ℃; for 1h; Reagent/catalyst; regioselective reaction;

DOI:10.1021/acs.orglett.7b01427

Reference yield: 93.0%

4-bromo-aniline (106-40-1) + Methacryloyl chloride (920-46-7,26937-45-1) → N-(4-bromophenyl)methacrylamide (7600-35-3)

Guidance literature:

With triethylamine; In dichloromethane; for 16h; Inert atmosphere;

DOI:10.1016/j.cclet.2021.05.053

Reference yield:

aniline (62-53-3) → N-(4-bromophenyl)methacrylamide (7600-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethyl acetate / 0 - 25 °C

2: Eosin Y; Selectfluor / acetonitrile / 1 h / 25 °C

With Eosin Y; Selectfluor; triethylamine; In ethyl acetate; acetonitrile;

DOI:10.1021/acs.orglett.7b01427

upstream raw materials:

poly(methacrylic acid)

4-bromo-aniline

Methacryloyl chloride

2-methyl-N-phenylacrylamide

Downstream raw materials:

(R)-N-(4-Bromo-phenyl)-3-((1S,2R,4R)-2-hydroxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-ylmethylsulfanyl)-2-methyl-propionamide

C₂₄H₁₈BrNO

N-methyl-N-(4-bromophenyl)methacrylamide

5-bromo-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one