2-[(Cyclohex-2-en-1-yl)oxy]-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-[(Cyclohex-2-en-1-yl)oxy]-1H-isoindole-1,3(2H)-dione
• CAS No.: 76029-42-0
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• DSSTox Substance ID: DTXSID50544227
• Nikkaji Number: J2.196.991E
• Mol file: 76029-42-0.mol

Synonyms:76029-42-0;2-[(Cyclohex-2-en-1-yl)oxy]-1H-isoindole-1,3(2H)-dione;2-cyclohex-2-en-1-yloxyisoindole-1,3-dione;SCHEMBL10854081;DTXSID50544227;QXFTXVXMRKJENL-UHFFFAOYSA-N;N-(2-cyclohexen-1-yl)oxyphthalimide;AKOS004910569;EN300-22028665;2-(cyclohex-2-en-1-yloxy)-2,3-dihydro-1H-isoindole-1,3-dione

Chemical Property of 2-[(Cyclohex-2-en-1-yl)oxy]-1H-isoindole-1,3(2H)-dione

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 243.08954328
• Heavy Atom Count: 18
• Complexity: 367

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC=CC(C1)ON2C(=O)C3=CC=CC=C3C2=O

Technology Process of 2-[(Cyclohex-2-en-1-yl)oxy]-1H-isoindole-1,3(2H)-dione

There total 4 articles about 2-[(Cyclohex-2-en-1-yl)oxy]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-hydroxyphthalimide (524-38-9) + rac-3-bromocyclohexene (1521-51-3,113667-32-6) → 2-(cyclohex-2-en-1-yloxy)isoindoline-1,3-dione (76029-42-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

Reference yield: 96.0%

N-hydroxyphthalimide (524-38-9) + Cyclohex-2-enol (822-67-3) → 2-(cyclohex-2-en-1-yloxy)isoindoline-1,3-dione (76029-42-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03126

Reference yield: 88.0%

N-hydroxyphthalimide (524-38-9) + cyclohexene (110-83-8) → 2-(cyclohex-2-en-1-yloxy)isoindoline-1,3-dione (76029-42-0)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 100 ℃; for 2h;

DOI:10.1039/c5ra12691f

upstream raw materials:

N-hydroxyphthalimide

Cyclohex-2-enol

cyclohexene

rac-3-bromocyclohexene

Downstream raw materials:

O-cyclohexylhydroxylamine hydrochloride

2-(cyclohexyloxy)-1H-isoindole-1,3(2H)-dione

C₆H₁₁NO*ClH

N-benzyl-O-(2-cyclohexenyl)hydroxylamine