1H-Isoindole-1,3(2H)-dione, 2-[3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-propynyl]-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-[3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-propynyl]-
CAS No.:76049-54-2
Molecular Formula:C24H13Cl2NO3
Molecular Weight:434.278
Hs Code.:

Synonyms:1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-phthalimidopropyne;1-[4- chloro-2-(2-chlorobenzoyl)phenyl]-3-phthalimidopropyne;

Suppliers and Price of 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-propynyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-propynyl]-

Chemical Property:

Melting Point:144-145 °C(Solv: acetone (67-64-1))
Boiling Point:633.7±55.0 °C(Predicted)
PSA：54.45000
Density:1.49±0.1 g/cm3(Predicted)
LogP:4.81000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-propynyl]-

There total 3 articles about 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-propynyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 7223-50-9
N-propargylphthalimide

: 76049-50-8
2',5-dichloro-2-iodobenzophenone

: 76049-54-2
N-<<4-chloro-2-(2-chlorobenzoyl)phenyl>-3-propynyl>isoindole-1,3(2H)-dione

Guidance literature:: With copper(l) iodide; diethylamine; triphenylphosphine; palladium dichloride; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jo00133a040

Reference yield:

: 2958-36-3,53960-29-5
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

: 76049-54-2
N-<<4-chloro-2-(2-chlorobenzoyl)phenyl>-3-propynyl>isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium nitrite, conc. sulfuric acid, 2.) aq. potassium iodide / 1.) 1 h, 2.) room temp., overnight

2: 39 percent / triphenylphosphine, palladium chloride, cuprous iodide, diethylamine / CH₂Cl₂ / 20 h / Ambient temperature

With copper(l) iodide; sulfuric acid; diethylamine; triphenylphosphine; potassium iodide; palladium dichloride; sodium nitrite; In dichloromethane;
DOI:10.1021/jo00133a040