76049-50-8Relevant academic research and scientific papers
Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution
Li, Quanzhe,Yu, Liuzhu,Wei, Yin,Shi, Min
supporting information, p. 9282 - 9296 (2019/08/12)
A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.
Cu(I)-Catalyzed Coupling and Cycloisomerization of Diazo Compounds with Terminal Yne-Alkylidenecyclopropanes: Synthesis of Functionalized Cyclopenta[ b]naphthalene Derivatives
Li, Peng-Hua,Yu, Liu-Zhu,Zhang, Xiao-Yu,Shi, Min
supporting information, p. 4516 - 4520 (2018/08/09)
A Cu(I)-catalyzed coupling and cycloisomerization of diazo compounds with terminal yne-alkylidenecyclopropanes (ACPs) has been presented. This reaction starts from the formation of an allenic intermediate in the Cu(I)-catalyzed cross-coupling reaction of a diazo compound with terminal alkyne in yne-tethered ACP and then undergoes a domino cycloisomerization of a 6π-electrocyclization and cyclopropane ring-opening rearrangement to give functionalized cyclopenta[b]naphthalene derivatives in moderate to excellent yields under mild conditions.
Compounds and methods for inhibiting mitotic progression
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Page/Page column 141-142, (2008/06/13)
This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat
3H-2-Benzazepines
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, (2008/06/13)
There is presented 3H-2-benzazepines and 4,5-dihydro-3H-2-benzazepines of the formula STR1 wherein X is hydrogen, chloro or bromo, Y is hydrogen, fluoro or chloro with the proviso that X and Y cannot both be hydrogen and R1 is selected from the
Pyrimido[4,5-d][2]benzazepines
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, (2008/06/13)
There is presented a compound of the formula STR1 wherein R1 is selected from the group consisting of hydrogen, lower alkyl, chloro, bromo, alkoxy, hydroxy, lower alkyl substituted thio and NR4 R5 wherein R4 and
2-Benzazepines. 1. Synthesis of 2-Benzazepin-4-ones and -5-ones via 2-Acetylenic Benzophenones
Trybulski, Eugene J.,Reeder, Earl,Blount, John F.,Walser, Armin,Fryer, R. Ian
, p. 2441 - 2447 (2007/10/02)
The preparation of 1-phenyl-2-benzazepin-4-ones and -5-ones is discussed.The palladium-catalyzed coupling of an iodobenzophenone to a monosubstituted acetylene assembles the necessary atoms required for the benzazepine ring.Transformation of the acetylene
Intermediates in the production of 2-benzazepines
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, (2008/06/13)
Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ
Triazolobenzazepines and processes for their production
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, (2008/06/13)
There is presented triazolobenzazepines of the formula STR1 wherein R1 is hydrogen or lower alkyl and X and Y are hydrogen or halogen and the pharmaceutically acceptable salts thereof. Also disclosed are novel processes and intermediates leadin
