5-Bromo-1,1-(ethylenedioxo)-indane

Base Information

• Chemical Name: 5-Bromo-1,1-(ethylenedioxo)-indane
• CAS No.: 760995-51-5
• Molecular Formula: C11H11BrO2
• Molecular Weight: 255.10800
• Hs Code.: 2914700090
• Mol file: 760995-51-5.mol

Synonyms:5'-Bromo-2',3'-dihydrospiro[[1,3]dioxolane-2,1'-indene];

Chemical Property of 5-Bromo-1,1-(ethylenedioxo)-indane

Chemical Property:

• Boiling Point: 325.2±42.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.59±0.1 g/cm3(Predicted)
• LogP: 2.59490

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-indan-1-one1,2-ethanediolketal 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1,1-(ethylenedioxo)-indane

There total 2 articles about 5-Bromo-1,1-(ethylenedioxo)-indane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-Bromo-1-indanone (34598-49-7) + ethylene glycol (107-21-1) → 5-bromo-2,3-dihydrospiro[indene-1,2'-[1 ,3]dioxolane] (760995-51-5)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1021/jm061223o

Reference yield:

→ 5-bromo-2,3-dihydrospiro[indene-1,2'-[1 ,3]dioxolane] (760995-51-5)

Guidance literature:

Reference yield:

5-bromo-2,3-dihydrospiro[indene-1,2'-[1 ,3]dioxolane] (760995-51-5) → 6-[(4-methyl-1-piperazinyl)methyl]-3-[5-(3-phenoxy-1-propynyl)-3-thienyl]-1,4-dihydroindeno[1,2-c]pyrazole

Guidance literature:

Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: 78 percent / tetrahydrofuran / -78 - 20 °C

2.1: 85 percent / NaBH₄ / methanol; tetrahydrofuran / 0 - 20 °C

3.1: 69 percent / p-TsOH / H₂O; acetone / Heating

4.1: 96 percent / Et₃N / tetrahydrofuran / 0 °C

5.1: 68 percent / K₂CO₃ / methanol / 0 - 20 °C

6.1: NaH / benzene / 2.5 h / Heating

7.1: 524 mg / hydrazine monohydrate; HOAc / ethanol / 4 h / Heating

8.1: 62 percent / PPh₃; Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 0.42 h / 120 °C / microwave irradiation

With sodium tetrahydroborate; n-butyllithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetone; benzene; 8.1: Sonogashira coupling;

DOI:10.1021/jm061223o

upstream raw materials:

5-Bromo-1-indanone

ethylene glycol

Downstream raw materials:

5-(2-hydroxyethyl)indan-1-one

2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione

3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-yn-1-amine