4-Phenacyl-azetidin-2-one

Base Information

• Chemical Name: 4-Phenacyl-azetidin-2-one
• CAS No.: 76127-62-3
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• DSSTox Substance ID: DTXSID20508538
• Mol file: 76127-62-3.mol

Synonyms:76127-62-3;4-phenacyl-azetidin-2-one;SCHEMBL9782613;DTXSID20508538;AKOS015907080;4-(2-oxo-2-phenylethyl)-2-azetidinone;4-(2-Oxo-2-phenylethyl)azetidin-2-one

Chemical Property of 4-Phenacyl-azetidin-2-one

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 244

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NC1=O)CC(=O)C2=CC=CC=C2

Technology Process of 4-Phenacyl-azetidin-2-one

There total 4 articles about 4-Phenacyl-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-styrenyloxytrimethylsilane (13735-81-4) + 4-Acetoxy-1-(trimethylsilyl)azetidin-2-one (80675-59-8) → 4-phenylcarbonylmethyl-2-azetidinone (76127-62-3)

Guidance literature:

trimethylsilyl trifluoromethanesulfonate; In dichloromethane; 1.) -78 deg C, 15 min 2.) room temperature, 30 min;

DOI:10.1021/jo00184a001

Reference yield: 83.0%

1-styrenyloxytrimethylsilane (13735-81-4) + 4-acetoxy azetidinone (28562-53-0) → 4-phenylcarbonylmethyl-2-azetidinone (76127-62-3)

Guidance literature:

With zinc(II) iodide; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(00)86836-7

Reference yield: 33.0%

4-acetoxy azetidinone (28562-53-0) + α-bromoacetophenone (70-11-1) → 4-phenylcarbonylmethyl-2-azetidinone (76127-62-3)

Guidance literature:

With diethylaluminium chloride; zinc; In tetrahydrofuran; at -10 - -5 ℃; for 1h;

DOI:10.1248/cpb.28.3494

upstream raw materials:

1-styrenyloxytrimethylsilane

4-acetoxy azetidinone

4-Acetoxy-1-(trimethylsilyl)azetidin-2-one

acetophenone

Downstream raw materials:

methyl 2-(4-phenylcarbonylmethyl-2-oxo-1-azetidinyl)-2-hydroxyacetate

Hydroxy-[2-oxo-4-(2-oxo-2-phenyl-ethyl)-azetidin-1-yl]-acetic acid benzyl ester

[2-Oxo-4-(2-oxo-2-phenyl-ethyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzyl ester

methyl 2-(4-phenylcarbonylmethyl-2-oxo-1-azetidinyl)-2-(triphenylphosphoranylidene)acetate