3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid

Base Information

Chemical Name:3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid
CAS No.:65594-96-9
Molecular Formula:C₁₉H₁₅NO₆
Molecular Weight:353.331
Hs Code.:2925190090
ChEMBL ID:CHEMBL1498991
DSSTox Substance ID:DTXSID20409177

Synonyms:3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid;3-[4-(acetyloxy)phenyl]-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoic acid;65594-96-9;345585-35-5;3-(4-acetyloxyphenyl)-2-(1,3-dioxoisoindol-2-yl)propanoic Acid;MLS001172578;CHEMBL1498991;DTXSID20409177;HMS2852N14;AKOS001074247;AKOS016879738;SMR000588550;CS-0219549;EN300-04309;SR-01000036826;SR-01000036826-1

Suppliers and Price of 3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(4-ACETOXY-PHENYL)-2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID 95.00%
5G
$ 1168.42

American Custom Chemicals Corporation
3-(4-ACETOXY-PHENYL)-2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID 95.00%
2.5G
$ 983.88

American Custom Chemicals Corporation
3-(4-ACETOXY-PHENYL)-2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID 95.00%
1G
$ 721.57

Total 5 raw suppliers

Chemical Property of 3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid

Chemical Property:

Vapor Pressure:2.86E-13mmHg at 25°C
Boiling Point:557.6°Cat760mmHg
Flash Point:291°C
PSA：100.98000
Density:g/cm³
LogP:1.84170
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:353.08993720
Heavy Atom Count:26
Complexity:571

Purity/Quality:

99% ^*data from raw suppliers

3-(4-ACETOXY-PHENYL)-2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OC1=CC=C(C=C1)CC(C(=O)O)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of 3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid

There total 2 articles about 3-(4-Acetoxy-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 6636-22-2,36534-47-1
O-acetyl-L-tyrosine

: 65594-96-9
O-Acetyl-N-phthaloyltyrosin

Guidance literature:: With acetic acid; Reflux; Schlenk technique;
DOI:10.1002/adsc.201300838

Reference yield:

: 65594-96-9
O-Acetyl-N-phthaloyltyrosin

Guidance literature:: N-Phthaloyltyrosin, Ac2O;

Reference yield:

: 65594-96-9
O-Acetyl-N-phthaloyltyrosin

: 1583285-46-4
(S)-4-(3-diazo-3-(diethoxyphosphoryl)-2-(1,3-dioxoisoindolin-2-yl)propyl)phenyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / Reflux; Schlenk technique

2: dichloromethane / 20 °C / Schlenk technique

3: hydrogenchloride / tetrahydrofuran / 20 °C / Schlenk technique

4: triethylamine / dichloromethane / 20 °C / Schlenk technique

With hydrogenchloride; thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 2: |Arbuzov Reaction;
DOI:10.1002/adsc.201300838