88050-23-1Relevant academic research and scientific papers
Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions. 4. Intermolecular reactions with 1,2,4-triazines
Lahue, Brian R.,Wan, Zhao-Kui,Snyder, John K.
, p. 4345 - 4354 (2007/10/03)
Intermolecular inverse electron demand cycloadditions of 2-substituted imidazoles with various 1,2,4-triazines produced both imidazo[4,5-c]pyridines (3-deazapurines) and pyrido[3,2-d]pyrimid-4-ones (8-deazapteridines). The product distribution was control
SYNTHESIS OF AN N-MUSTARD PRODRUG
Mann, John,Haase-Held, Margret,Springer, Caroline J.,Bagshawe, Kenneth D.
, p. 5377 - 5382 (2007/10/02)
We describe the synthesis of the novel N-mustard prodrug 4-benzoyl-L-glutamic acid, which is designed for activation by tumour localising antibody-carboxypeptidase conjugates.
Novel Prodrugs Which Are Activated to Cytotoxic Alkylating Agents by Carboxypeptidase G2
Springer, Caroline J.,Antoniw, Pari,Bagshawe, Kenneth D.,Searle, Frances,Bisset, Graham M. F.,Jarman, Michael
, p. 677 - 681 (2007/10/02)
The synthesis of three novel prodrugs, 4-amino>benzoyl-L-glutamic acid (7), 4-amino>benzoyl-L-glutamic acid (8), and 4-benzoyl-L-glutamic acid (9), for use as anticancer ag
Chemistry and Antitumor Evaluation of Selected Classical 2,4-Diaminoquinazoline Analogues of Folic Acid
Hynes, J.B.,Harmon, S.J.,Floyd, G.G.,Farrington, M.,Hart, L.D.,et al.
, p. 209 - 215 (2007/10/02)
A series of six 2,4-diaminoquinazoline analogues of folic acid which bear close structural resemblance to methotrexate, 1a, were synthesized by unequivocal routes.Three of these have not been described previously, while complete structural characterizatio
