6-Dimethylaminonicotinamide

Base Information

• Chemical Name: 6-Dimethylaminonicotinamide
• CAS No.: 36507-21-8
• Molecular Formula: C₈H₁₁N₃O
• Molecular Weight: 165.195
• Hs Code.: 2933399090
• NSC Number: 73291
• UNII: L7VJ50456Q
• DSSTox Substance ID: DTXSID30190009
• Wikidata: Q83062251
• ChEMBL ID: CHEMBL1997189
• Mol file: 36507-21-8.mol

Synonyms:6-dimethylaminonicotinamide

Chemical Property of 6-Dimethylaminonicotinamide

Chemical Property:

• Vapor Pressure: 5.34E-05mmHg at 25°C
• Melting Point: 231-232 °C
• Boiling Point: 347.5°Cat760mmHg
• PKA: 15.72±0.50(Predicted)
• Flash Point: 164°C
• PSA: 59.22000
• Density: 1.185g/cm³
• LogP: 0.94680
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.090211983
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

6-(Dimethylamino)nicotinamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=NC=C(C=C1)C(=O)N

Technology Process of 6-Dimethylaminonicotinamide

There total 2 articles about 6-Dimethylaminonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

6-chloro-3-pyridinecarboxamide (6271-78-9) + dimethyl amine (124-40-3) → 6-(dimethylamino)pyridine-3-carboxamide (36507-21-8)

Guidance literature:

In water; N,N-dimethyl-formamide; for 12h;

DOI:10.1016/j.bmcl.2018.01.058

Reference yield:

→ 6-(dimethylamino)pyridine-3-carboxamide (36507-21-8)

Guidance literature:

6-Chlornicotinamid, Me2NH;

DOI:10.1021/jm00278a017

Reference yield:

6-(dimethylamino)pyridine-3-carboxamide (36507-21-8) → 5-(aminomethyl)-N,N-dimethylpyridin-2-amine (354824-17-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jf072851x

upstream raw materials:

6-chloro-3-pyridinecarboxamide

dimethyl amine

Downstream raw materials:

5-(aminomethyl)-N,N-dimethylpyridin-2-amine

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