4-ISOBUTYLQUINOLINE

Base Information

• Chemical Name: 4-ISOBUTYLQUINOLINE
• CAS No.: 7661-51-0
• Molecular Formula: C13H15N
• Molecular Weight: 185.269
• Hs Code.: 2933499090
• Mol file: 7661-51-0.mol

Synonyms:4-ISOBUTYLQUINOLINE;4-Isobutyl-chinolin;

Chemical Property of 4-ISOBUTYLQUINOLINE

Chemical Property:

• Boiling Point: 298.0±9.0 °C(Predicted)
• PKA: 5.55±0.46(Predicted)
• PSA: 12.89000
• Density: 1.012±0.06 g/cm3(Predicted)
• LogP: 3.43330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ISOBUTYLQUINOLINE

There total 4 articles about 4-ISOBUTYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

quinoline (91-22-5) + Isobutyl bromide (78-77-3) → 4-isobutylquinoline (7661-51-0)

Guidance literature:

With bis(acetylacetonato)palladium(II); caesium carbonate; trimethylphosphane; In toluene; at 70 ℃; for 6h;

Reference yield: 87.0%

4-chloroquinoline (611-35-8) + 2-methylpropylmagnesium chloride (5674-02-2) → 4-isobutylquinoline (7661-51-0)

Guidance literature:

manganese(ll) chloride; In tetrahydrofuran; at 0 ℃; for 5h;

DOI:10.1055/s-2007-968013

Reference yield: 78.0%

4-chloroquinoline (611-35-8) + 3-methyl-1-(pyridin-2-yl) butan-1-one (6952-53-0) → 4-isobutylquinoline (7661-51-0)

Guidance literature:

With 2.9-dimethyl-1,10-phenanthroline; palladium(II) trifluoroacetate; potassium tert-butylate; In toluene; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02498

upstream raw materials:

quinoline

3-methylbutyric acid

4-chloroquinoline

2-methylpropylmagnesium chloride

Refernces

• 1、 -. "Method for synthesizing substituted quinoline derivative 4- through palladium catalysis (by machine translation)". Paragraph 0035-0040. . Retrieved 2020/01/08.
• 2、 Rueping, Magnus,Ieawsuwan, Winai. "A manganese-catalyzed cross-coupling reaction". . p. 247 - 250. Retrieved 2007/10/03.