2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Base Information

Chemical Name:2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
CAS No.:76781-25-4
Molecular Formula:C18H23N5
Molecular Weight:309.414
Hs Code.:
DSSTox Substance ID:DTXSID00504073
Wikidata:Q82358310

Synonyms:2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine;76781-25-4;SCHEMBL11290070;DTXSID00504073

Suppliers and Price of 2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:309.19534575
Heavy Atom Count:23
Complexity:376

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C1)C(=NC(=N2)N3CCN(CC3)C4=CC=CC=C4)N

Technology Process of 2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

There total 5 articles about 2-(4-Phenylpiperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 92-54-6
4-phenyl-1-piperazine

: 1127-86-2
4-amino-2-chloro-5,6,7,8-tetrahydroquinazoline

: 76781-25-4
2-(4-Phenylpiperazino)-4-amino-5,6-tetramethylenepyrimidine

Guidance literature:: With 4-methyl-morpholine; In i-Amyl alcohol; at 180 ℃; for 5h;

Reference yield:

: 1127-85-1
2,4-dichloro-5,6,7,8-tetrahydro-quinazoline

: 76781-25-4
2-(4-Phenylpiperazino)-4-amino-5,6-tetramethylenepyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / aqu. ammonia / ethanol / 100 °C

2: 85 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C

With 4-methyl-morpholine; ammonium hydroxide; In ethanol; i-Amyl alcohol;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 76781-25-4
2-(4-Phenylpiperazino)-4-amino-5,6-tetramethylenepyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethylate

2: phosphorous oxychloride

3: 75 percent / aqu. ammonia / ethanol / 100 °C

4: 85 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C

With 4-methyl-morpholine; ammonium hydroxide; sodium ethanolate; trichlorophosphate; In ethanol; i-Amyl alcohol;