DIETHYL (4-PYRIDINEMETHYL) PHOSPHONATE

Base Information

• Chemical Name: DIETHYL (4-PYRIDINEMETHYL) PHOSPHONATE
• CAS No.: 77047-42-8
• Molecular Formula: C10H16NO3P
• Molecular Weight: 229.216
• Mol file: 77047-42-8.mol

Synonyms:Methojodid des N,N-Diaethyl-glycin-[2,6-dimethyl-anilids;diethyl 4-pyridylmethylphosphonate;diethyl[(pyridin-4-yl)methyl]phosphonate;Ammonium,diethylmethyl((2,6-dimethylcarbaniloyl)methyl)-,iodide;Lidocaine methiodide;N-methyllidocaine iodide;Ethaneaminium,2-((2,6-dimethylphenyl)amino)-N,N-diethyl-N-methyl-2-oxo-,iodide;Diaethyl-[(2,6-dimethyl-phenylcarbamoyl)-methyl]-methyl-ammonium,Jodid;Diethylmethyl((2,6-xylylcarbamoyl)methyl)ammonium iodide;Diethylmethyl((2,6-dimethylcarbaniloyl)methyl)ammonium iodide;pyridin-4-ylmethyl-phosphonic acid diethyl ester;diethyl-[(2,6-dimethyl-phenylcarbamoyl)-methyl]-methyl-ammonium,iodide;4-<(diethylphosphono)methyl>pyridine;Methyllidocaine iodide;

Chemical Property of DIETHYL (4-PYRIDINEMETHYL) PHOSPHONATE

Chemical Property:

• Boiling Point: 89 °C(Press: 0.05 Torr)
• PKA: 5.33±0.10(Predicted)
• PSA: 58.23000
• Density: 1.135±0.06 g/cm3(Predicted)
• LogP: 2.84770

Purity/Quality:

97% ^*data from raw suppliers

DIETHYL (4-PYRIDINYL)METHYL PHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DIETHYL (4-PYRIDINEMETHYL) PHOSPHONATE

There total 11 articles about DIETHYL (4-PYRIDINEMETHYL) PHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Diethyl phosphonate (762-04-9,123-22-8) + 4-picolylchloride hydrochloride (1822-51-1) → 4-<(diethylphosphono)methyl>pyridine (77047-42-8)

Guidance literature:

4-picolylchloride hydrochloride; With sodium carbonate; In water; at 20 ℃; for 0.0333333h;

Diethyl phosphonate; With sodium hydride; In toluene; at 80 ℃; for 0.5h;

DOI:10.1039/c5cc01002k

Reference yield:

4-(Chloromethyl)pyridine (10445-91-7) + phosphonic acid diethyl ester (762-04-9) → 4-<(diethylphosphono)methyl>pyridine (77047-42-8)

Guidance literature:

With sodium hydroxide; sodium; Yield given. Multistep reaction; 1.) benzene, 2.) reflux, 2 h;

DOI:10.1246/bcsj.63.2438

Reference yield:

pyridine-4-methanol (586-95-8) → 4-<(diethylphosphono)methyl>pyridine (77047-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / SOCl₂ / 3 h / Heating

2: 1.) Na / 1.) C₆H₆, reflux, 30 min, 2.) C₆H₆, 30 min

With thionyl chloride; sodium;

upstream raw materials:

4-(Chloromethyl)pyridine

Diethyl phosphonate

phosphonic acid diethyl ester

4-(bromomethyl)pyridine

Downstream raw materials:

<(1-benzylpyridino)-4-methyl>phosphonic acid

(4-Pyridylmethyl)phosphonic acid

cis-4-(phosphonomethyl)piperidine-2-carboxylic acid

C₃₉H₃₀N₄