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10445-91-7

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10445-91-7 Usage

Description

4-(Chloromethyl)pyridine is a halogenated heterocyclic compound characterized by a pyridine ring, which is a six-membered ring containing five carbon atoms and one nitrogen atom, with a chloromethyl substituent attached to one of its carbon atoms. This chemical compound is typically found as a clear, colorless liquid with a distinctive odor. It plays a significant role in the chemical industry, particularly in the synthesis of pharmaceuticals, agrochemicals, and other complex organic compounds. However, it requires careful handling due to potential health risks, such as causing burns and eye damage if mishandled.

Uses

Used in Pharmaceutical Industry:
4-(Chloromethyl)pyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(Chloromethyl)pyridine serves as a crucial building block for the creation of novel agrochemicals. Its incorporation into these compounds can enhance their effectiveness in protecting crops from pests and diseases, thereby improving agricultural productivity and food security.
Used in Organic Synthesis:
4-(Chloromethyl)pyridine is utilized as a versatile reagent in organic synthesis, enabling the formation of a wide range of complex organic compounds. Its presence in these reactions can facilitate the creation of new molecules with diverse applications, such as in materials science, chemical research, and the development of new technologies.
Overall, 4-(Chloromethyl)pyridine is a valuable chemical compound with diverse applications across various industries, particularly in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it an essential component in the development of innovative products and solutions. However, its potential health risks necessitate proper handling and safety precautions to ensure the well-being of those working with this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 10445-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,4 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 10445-91:
(7*1)+(6*0)+(5*4)+(4*4)+(3*5)+(2*9)+(1*1)=77
77 % 10 = 7
So 10445-91-7 is a valid CAS Registry Number.

10445-91-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(Chloromethyl)pyridine

1.2 Other means of identification

Product number -
Other names chloromethylpyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10445-91-7 SDS

10445-91-7Relevant articles and documents

Efficient synthesis of a new series of piperidine ring-modified analogs of (±)-threo-methyl phenyl(piperidin-2-yl)acetate

Ojo, Babatunde

, p. 1731 - 1745 (2012)

A series of novel piperidine ring modified analogs of (±)-threo- methyl phenyl (piperidin-2-yl)acetate was synthesized by direct alkylation and reductive amination procedure, using sodium borohydride over molecular sieves. The chemical structures of these compounds were established based on mass spectra, 1H NMR spectra, and CHN elemental analysis data. Several significant modifications in the literature methodologies were made to make the reaction more efficient, and good yields were generally obtained. Copyright Taylor & Francis Group, LLC.

Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors

Yan, Yu-Hang,Li, Wenfang,Chen, Wei,Li, Chao,Zhu, Kai-Rong,Deng, Ji,Dai, Qing-Qing,Yang, Ling-Ling,Wang, Zhenling,Li, Guo-Bo

, (2021/11/17)

Production of metallo-β-lactamases (MBLs) in bacterial pathogens is an important cause of resistance to the ‘last-resort’ carbapenem antibiotics. Development of effective MBL inhibitors to reverse carbapenem resistance in Gram-negative bacteria is still needed. We herein report X-ray structure-guided optimization of 1H-imidazole-2-carboxylic acid (ICA) derivatives by considering how to engage with the active-site flexible loops and improve penetration into Gram-negative bacteria. Structure-activity relationship studies revealed the importance of appropriate substituents at ICA 1-position to achieve potent inhibition to class B1 MBLs, particularly the Verona Integron-encoded MBLs (VIMs), mainly by involving ingenious interactions with the flexible active site loops as observed by crystallographic analyses. Of the tested ICA inhibitors, 55 displayed potent synergistic antibacterial activity with meropenem against engineered Escherichia coli strains and even intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL. The morphologic and internal structural changes of bacterial cells after treatment further demonstrated that 55 crossed the outer membrane and reversed the activity of meropenem. Moreover, 55 showed good pharmacokinetic and safety profile in vivo, which could be a potential candidate for combating VIM-mediated Gram-negative carbapenem resistance.

1 - Substituted - 111H-imidazol -2 - carboxylic acid compound (by machine translation)

-

Paragraph 0228-0230, (2020/07/02)

The invention relates to 1 - substituted - 111H-imidazol -2 - carboxylic acid compounds. Experiments prove that the compound provided by the invention can effectively inhibit the activity of various MBL enzymes including VIM-2, NDM-1, ?currcurrcurrcurry ?, VIM-IMP-1 1 and VIM IM IM, especially compounds 11 and 13, 14, 29, 30, 34, 37, 40, and IC of VIM-2 type MBL enzyme. 50 The value is below 2.13 μm, the inhibition effect is more remarkable than that of the positive control medicine, and the MBL enzyme inhibitor has great potential in preparing the MBL enzyme inhibitor. , The compound is combined with β - lactam antibiotics, metal β - lactamase produced by drug-resistant bacteria can be effectively inhibited, the antibacterial activity of the antibiotic is enhanced, and the compound has a very good application prospect in preparation of antibacterial and combined medicines. (by machine translation)

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