5'-NITRO-O-FORMOTOLUIDIDE

Base Information

• Chemical Name: 5'-NITRO-O-FORMOTOLUIDIDE
• CAS No.: 77252-56-3
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.163
• Mol file: 77252-56-3.mol

Synonyms:N-(2-Methyl-5-nitro-phenyl)-formamide;N-formyl-2-methyl-5-nitroaniline;Ameisensaeure-(2-methyl-5-nitro-anilid);formic acid-(2-methyl-5-nitro-anilide);4-Nitro-2-formamino-toluol;

Chemical Property of 5'-NITRO-O-FORMOTOLUIDIDE

Chemical Property:

• Melting Point: 178 - 179 °C (H2O)
• PSA: 74.92000
• LogP: 2.70360

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-NITRO-O-FORMOTOLUIDIDE

There total 2 articles about 5'-NITRO-O-FORMOTOLUIDIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N'-(2-methyl-5-nitrophenyl)-N,N-dimethylformamidine (36192-16-2) → N-(2-methyl-5-nitrophenyl)formamide (77252-56-3)

Guidance literature:

With zinc(II) chloride; In ethanol; at 25 ℃; for 24h;

DOI:10.1080/00397919408010163

Reference yield:

2-methyl-5-nitroaniline (99-55-8) → N-(2-methyl-5-nitrophenyl)formamide (77252-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 21 h / Heating

2: 81 percent / ZnCl₂ / ethanol / 24 h / 25 °C

With zinc(II) chloride; In ethanol;

DOI:10.1080/00397919408010163

Reference yield: 91.0%

N-(2-methyl-5-nitrophenyl)formamide (77252-56-3) + di-n-propylamine (142-84-7) → N'-(2-Methyl-5-nitro-phenyl)-N,N-dipropyl-formamidine (77486-39-6)

Guidance literature:

With phosphorus pentoxide; at 210 ℃; for 2h;

upstream raw materials:

N'-(2-methyl-5-nitrophenyl)-N,N-dimethylformamidine

2-methyl-5-nitroaniline

Downstream raw materials:

5-Nitro-2-methyl-phenyl-isocyaniddichlorid

N-Butyl-N-methyl-N'-(2-methyl-5-nitro-phenyl)-formamidine

N'-(2-Methyl-5-nitro-phenyl)-N,N-dipropyl-formamidine

N,N-Diethyl-N'-(2-methyl-5-nitro-phenyl)-formamidine