2-Isopropyl-3,4-dimethoxybenzaldehyde

Base Information

• Chemical Name: 2-Isopropyl-3,4-dimethoxybenzaldehyde
• CAS No.: 77256-02-1
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• DSSTox Substance ID: DTXSID70455048
• Wikidata: Q82276894
• Mol file: 77256-02-1.mol

Synonyms:2-Isopropyl-3,4-dimethoxybenzaldehyde;77256-02-1;3,4-dimethoxy-2-propan-2-ylbenzaldehyde;DTXSID70455048;CDA25602;CS-M0282;CS-13561;C11532

Chemical Property of 2-Isopropyl-3,4-dimethoxybenzaldehyde

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 208.109944368
• Heavy Atom Count: 15
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=C(C=CC(=C1OC)OC)C=O

Technology Process of 2-Isopropyl-3,4-dimethoxybenzaldehyde

There total 9 articles about 2-Isopropyl-3,4-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-bromo-2-isopropyl-3,4-dimethoxybenzene (77256-01-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-isopropyl-3,4-dimethoxybenzaldehyde (77256-02-1)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran;

DOI:10.1021/jo00328a029

Reference yield: 82.0%

4,4-dimethyl-2-(2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline (99425-55-5) → 2-isopropyl-3,4-dimethoxybenzaldehyde (77256-02-1)

Guidance literature:

4,4-dimethyl-2-(2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline; With methyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 2h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4020(98)00501-8

Reference yield:

hydrogen cyanide (74-90-8) + 3-Isopropyl-veratrol (71720-27-9) → 2-isopropyl-3,4-dimethoxybenzaldehyde (77256-02-1)

Guidance literature:

With hydrogenchloride; aluminium trichloride; benzene;

DOI:10.1021/ja01596a071

upstream raw materials:

hydrogen cyanide

3-Isopropyl-veratrol

1-bromo-2-isopropyl-3,4-dimethoxybenzene

N,N-dimethyl-formamide

Downstream raw materials:

4-Hydroxy-8-isopropyl-6,7-dimethoxy-2-naphthoic acid

t-butyl 3-methyl-4-oxo-4-(2-isopropyl-3,4-dimethoxyphenyl)butyrate

4-<3,4-dimethoxy-2-(1-methylethyl)phenyl>-3-methylbutanoic acid