7,8-dimethoxy-3,4-dihydroisoquinoline

Base Information

• Chemical Name: 7,8-dimethoxy-3,4-dihydroisoquinoline
• CAS No.: 75877-72-4
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 75877-72-4.mol

Synonyms:3,4-Dihydroisobackebergine;Dehydrolemaireocereine

Chemical Property of 7,8-dimethoxy-3,4-dihydroisoquinoline

Chemical Property:

• Vapor Pressure: 0.000276mmHg at 25°C
• Boiling Point: 332.8°C at 760 mmHg
• Flash Point: 126.6°C
• PSA: 30.82000
• Density: 1.13g/cm³
• LogP: 1.11440

Purity/Quality:

98.5% ^*data from raw suppliers

3,4-Dihydro-7,8-dimethoxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dihydro-7,8-dimethoxyisoquinoline is an intermediate in the synthesis of Tetrabenazine (T28400), a dopamine depleting agent. An antidyskinetic; antipsychotic.

Technology Process of 7,8-dimethoxy-3,4-dihydroisoquinoline

There total 3 articles about 7,8-dimethoxy-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,2,3,4-tetrahydro-7,8-dimethoxyisoquinoline (52759-08-7) → dehydrolemaireocereine (75877-72-4)

Guidance literature:

With potassium permanganate; In acetone; for 48h;

DOI:10.1002/jps.2600731137

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → dehydrolemaireocereine (75877-72-4)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)82136-X

Reference yield:

→ dehydrolemaireocereine (75877-72-4)

Guidance literature:

7,8-Dimethoxy-1,2,3,4-tetrahydro-isochinolin, Natriumhypochlorit;

DOI:10.1002/hlca.19700530726

upstream raw materials:

1,2,3,4-tetrahydro-7,8-dimethoxyisoquinoline

2-(3,4-dimethoxyphenyl)-ethylamine

N,N-dimethyl-formamide

Refernces

• 1、 -. "Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo [2,3-e]quinolizine derivatives". . . Retrieved 2008/06/13.
• 2、 Lamas, Carlos,Castedo, Luis,Dominguez, Domingo. "REGIOSELECTIVE SYNTHESIS OF 7,8-DIOXYGENATED-3,4-DIHYDROISOQUINOLINES BY METALATION OF β-PHENETHYLAMINES". . p. 3865 - 3868. Retrieved 2007/10/02.