Corosolic acid

Base Information

Chemical Name:Corosolic acid
CAS No.:4547-24-4
Molecular Formula:C₃₀H₄₈O₄
Molecular Weight:472.709
Hs Code.:2918195000
European Community (EC) Number:610-253-4
UNII:AMX2I57A98
DSSTox Substance ID:DTXSID70904142
Nikkaji Number:J14.066J
Wikipedia:Corosolic_acid
Wikidata:Q5172335
Pharos Ligand ID:X5XG53ZWLS5D
Metabolomics Workbench ID:133423
ChEMBL ID:CHEMBL391533
Mol file:4547-24-4.mol

Synonyms:2alpha-hydroxyursoloic acid;corosolic acid;Glucosol

Suppliers and Price of Corosolic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Corosolic acid
20mg
$ 326.00

TRC
(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oicAcid
100mg
$ 920.00

Sigma-Aldrich
Corosolic acid from Lagerstroemia speciosa ≥98% (HPLC)
10mg
$ 289.00

Sigma-Aldrich
Corosolic acid from Lagerstroemia speciosa ≥98% (HPLC)
50mg
$ 877.00

Sigma-Aldrich
Corosolic acid United States Pharmacopeia (USP) Reference Standard
50mg
$ 857.00

Sigma-Aldrich
Corosolic acid analytical standard
10mg
$ 352.00

Labseeker
Corosolic acid 98
20mg
$ 650.00

JR MediChem
Corosolic acid 98%
20mg
$ 1200.00

DC Chemicals
Corosolic acid >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
Corosolic acid 98+%
10mg
$ 77.00

Total 162 raw suppliers

Chemical Property of Corosolic acid

Chemical Property:

Appearance/Colour:Fine-Brown Yellow Powder
Vapor Pressure:1.56E-15mmHg at 25°C
Melting Point:243～245℃
Refractive Index:1.566
Boiling Point:573.3 °C at 760 mmHg
PKA:4.67±0.70(Predicted)
Flash Point:314.6 °C
PSA：77.76000
Density:1.14 g/cm³
LogP:6.06030
Storage Temp.:2-8°C
Solubility.:methanol: soluble1mg/mL, clear, colorless
XLogP3:6.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:472.35526001
Heavy Atom Count:34
Complexity:908

Purity/Quality:

95%-98% ^*data from raw suppliers

Corosolic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C)O)O)C)C)C2C1C)C)C(=O)O
Isomeric SMILES:C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H](C5(C)C)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O
Description Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID50 value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.
Uses (2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tumor activity (2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tum or activity

Technology Process of Corosolic acid

There total 14 articles about Corosolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%