Methyl corosolate

Base Information

• Chemical Name: Methyl corosolate
• CAS No.: 4518-70-1
• Molecular Formula: C31H50O4
• Molecular Weight: 486.736
• Mol file: 4518-70-1.mol

Synonyms:Urs-12-en-28-oicacid, 2a,3b-dihydroxy-, methyl ester (7CI,8CI);2a-Hydroxyursolic acid methyl ester;Methyl 2a-hydroxyursolate;Methylcorosolate;

Chemical Property of Methyl corosolate

Chemical Property:

• Melting Point: 212-214 deg.
• Boiling Point: 541.892 °C at 760 mmHg
• Flash Point: 163.088 °C
• PSA: 66.76000
• Density: 1.112 g/cm³
• LogP: 6.14870

Purity/Quality:

99% ^*data from raw suppliers

METHYL-COROSOLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl corosolate

There total 19 articles about Methyl corosolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

corosolic acid (4547-24-4,52213-27-1,72881-13-1,87205-98-9,114580-53-9) + methyl iodide (74-88-4) → methyl corosolate (4518-70-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 16h;

Reference yield: 71.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + corosolic acid (4547-24-4,52213-27-1,72881-13-1,87205-98-9,114580-53-9) → methyl corosolate (4518-70-1)

Guidance literature:

In diethyl ether; chloroform; at 20 ℃;

DOI:10.1016/j.ejmech.2008.05.024

Reference yield:

methyl 2a-hydroxy-3-oxours-12-en-28-oate (919092-94-7) → methyl corosolate (4518-70-1) + methyl 2α,3α-dihydroxyurs-12-en-28-oate (52213-28-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

upstream raw materials:

diazomethane

corosolic acid

methyl 3-oxooleanolate

3-Acetoxy-ursadien-(2.12)-saeure-⁽²⁸⁾-methylester

Downstream raw materials:

corosolic acid

2α,3β,28-trihydroxyurs-12-ene

Refernces

• 1、 Arthur,Hui. "-". . p. 1403,1405. Retrieved 1954.
• 2、 Wen, Xiaoan,Xia, Jun,Cheng, Keguang,Zhang, Liying,Zhang, Pu,Liu, Jun,Zhang, Luyong,Ni, Peizhou,Sun, Hongbin. "Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases". . p. 5777 - 5782. Retrieved 2008/04/03.