(3-Methyl-2-oxobutyl)phosphonic acid diethyl ester

Base Information

• Chemical Name: (3-Methyl-2-oxobutyl)phosphonic acid diethyl ester
• CAS No.: 7751-67-9
• Molecular Formula: C9H19O4P
• Molecular Weight: 222.221
• Mol file: 7751-67-9.mol

Synonyms:diethyl isobutyrylmethylphosphonate;diethylphosphono-3-methyl-2-butanone;

Chemical Property of (3-Methyl-2-oxobutyl)phosphonic acid diethyl ester

Chemical Property:

• PSA: 62.41000
• Density: 1.050
• LogP: 2.47760

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Methyl-2-oxobutyl)phosphonic acid diethyl ester

There total 11 articles about (3-Methyl-2-oxobutyl)phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Chlor-2-isopropyloxiran (76002-26-1) + triethyl phosphite (122-52-1) → diethyl isobutyrylmethylphosphonate (7751-67-9)

Guidance literature:

In dichloromethane; Ambient temperature;

Reference yield: 60.0%

1-bromo-3-methyl-2-butanone (19967-55-6) + triethyl phosphite (122-52-1) → diethyl isobutyrylmethylphosphonate (7751-67-9)

Guidance literature:

at 120 ℃; for 3h;

DOI:10.1021/jo971405d

Reference yield: 60.0%

2,6-dimethyl-3,5-heptanedione (18362-64-6) + phosphonic acid diethyl ester (762-04-9) → diethyl isobutyrylmethylphosphonate (7751-67-9)

Guidance literature:

With dipotassium peroxodisulfate; silver(I) acetate; In water; N,N-dimethyl-formamide; at 85 ℃; for 24h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201704910

upstream raw materials:

diethyl chloromethylphosphonate

isobutyraldehyde

Diethyl methylphosphonate

isobutyryl chloride

Downstream raw materials:

(5α,7α,24R)-7,24-dihydroxy-3-ketocholestane

(5α,7α)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate

Refernces

• 1、 Li, Lili,Huang, Wenbin,Chen, Lijin,Dong, Jiaxing,Ma, Xuebing,Peng, Yungui. "Silver-Catalyzed Oxidative C(sp3)?P Bond Formation through C?C and P?H Bond Cleavage". supporting information. p. 10539 - 10544. Retrieved 2017/08/22.
• 2、 Gil, Jun Mo,Hah, Jung Hwan,Park, Kwang Young,Oh, Dong Young. "One pot synthesis of mono- and spirocyclic α-phosphonato-α,β- unsaturated cycloenones". . p. 3205 - 3208. Retrieved 2007/10/03.