Ethanone, 1-(4-nitrophenyl)-, phenylhydrazone

Base Information

• Chemical Name: Ethanone, 1-(4-nitrophenyl)-, phenylhydrazone
• CAS No.: 77635-72-4
• Molecular Formula: C14H13N3O2
• Molecular Weight: 255.276
• Mol file: 77635-72-4.mol

Synonyms:4-Nitro-acetophenon-phenylhydrazon;p-Nitroacetophenon-phenylhydrazon;1-(4-Nitro-phenyl)-aethanon-phenylhydrazon;1-(4-nitro-phenyl)-ethanone-phenylhydrazone;

Chemical Property of Ethanone, 1-(4-nitrophenyl)-, phenylhydrazone

Chemical Property:

• Melting Point: 132-134 °C
• Boiling Point: 406.4±47.0 °C(Predicted)
• PSA: 70.21000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 4.02710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(4-nitrophenyl)-, phenylhydrazone

There total 4 articles about Ethanone, 1-(4-nitrophenyl)-, phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylhydrazine (100-63-0) + (4-nitrophenyl)ethanone (100-19-6) → 1-(4-nitro-phenyl)-ethanone-phenylhydrazone (77635-72-4)

Guidance literature:

With oxaline; In neat (no solvent); at 25 - 30 ℃; for 0.05h; Green chemistry;

DOI:10.1016/j.molliq.2013.11.036

Reference yield: 88.0%

phenylhydrazine (100-63-0) + (4-nitrophenyl)ethanone (100-19-6) → (E)?1-(1-(4-nitrophenyl)ethylidene)-2-phenylhydrazine (77635-72-4)

Guidance literature:

With acetic acid; In ethanol; at 0 - 15 ℃; for 0.5h;

DOI:10.1016/j.molstruc.2021.130223

Reference yield: 87.0%

phenylhydrazine hydrochloride (59-88-1) + (4-nitrophenyl)ethanone (100-19-6) → 1-(4-nitro-phenyl)-ethanone-phenylhydrazone (77635-72-4)

Guidance literature:

In ethanol; for 1h; Heating;

DOI:10.1021/jm00137a011

upstream raw materials:

phenylhydrazine

(4-nitrophenyl)ethanone

phenylhydrazine hydrochloride

Downstream raw materials:

1-phenyl-3-(4-nitrophenyl)-1H-pyrazole-4-carboxaldehyde semicarbazone

2-amino-1-(4-fluorophenyl)-4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-amino-1-(4-fluorophenyl)-7,7-dimethyl-4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-amino-1-(4-(4-fluorophenyl)thiazol-2-yl)-4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Refernces

• 1、 Azimi, Fateme,Ghasemi, Jahan B.,Azizian, Homa,Najafi, Mohammad,Faramarzi, Mohammad Ali,Saghaei, Lotfollah,Sadeghi-aliabadi, Hojjat,Larijani, Bagher,Hassanzadeh, Farshid,Mahdavi, Mohammad. "Design and synthesis of novel pyrazole-phenyl semicarbazone derivatives as potential α-glucosidase inhibitor: Kinetics and molecular dynamics simulation study". . p. 1082 - 1095. Retrieved 2020/11/20.
• 2、 Alenezi, Khalaf M.,Alshammari, Musherah M.,Haque, Ashanul,Mushtque, Md.,Rizvi, M. Moshahid Alam,Soury, Raoudha. "Synthesis, characterization, anticancer and in silico studies of a pyrazole-tethered thiazolidine-2,4-dione derivative". . . Retrieved 2021/09/28.