Pyridine, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,2-dihydro-1-[(E)-[[(1S)-1-( methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-2-phenyl-, (2R)-

Base Information

Chemical Name:Pyridine, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,2-dihydro-1-[(E)-[[(1S)-1-( methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-2-phenyl-, (2R)-
CAS No.:777944-33-9
Molecular Formula:C33H32F6N2O2
Molecular Weight:602.62
Hs Code.:

Pyridine,
3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,2-dihydro-1-[(E)-[[(1S)-1-(
methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-2-phenyl-, (2R)-

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Chemical Property of Pyridine, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,2-dihydro-1-[(E)-[[(1S)-1-( methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-2-phenyl-, (2R)-

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Technology Process of Pyridine, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,2-dihydro-1-[(E)-[[(1S)-1-( methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-2-phenyl-, (2R)-

There total 3 articles about Pyridine, 3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-1,2-dihydro-1-[(E)-[[(1S)-1-( methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-2-phenyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: phenylmagnesium bromide

: 87768-46-5
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide

: 207509-50-0
3-{[3,5-bis(trifluoromethyl)benzyl]oxy}pyridine

: 777944-33-9
N-(1E)-[(2R)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenyl-2H-pyridin-1-yl]-N-[(S)-2-(1-methoxy-3-methylbutyl)]-benzamidine

Guidance literature:: N-[(1S)-1-(methoxymethyl)-2-methylpropyl]benzamide; 3-{[3,5-bis(trifluoromethyl)benzyl]oxy}pyridine; With trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 3h;

phenylmagnesium bromide; In dichloromethane; at -40 - -10 ℃; for 4h;
DOI:10.1021/ol048624n

Reference yield:

: 109-00-2
3-HYDROXYPYRIDINE

: 777944-33-9
N-(1E)-[(2R)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenyl-2H-pyridin-1-yl]-N-[(S)-2-(1-methoxy-3-methylbutyl)]-benzamidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / NaH / dimethylformamide / 20 h / 20 °C

2.1: Tf₂O / CH₂Cl₂ / 3 h / 20 °C

2.2: 84 percent / CH₂Cl₂ / 4 h / -40 - -10 °C

With trifluoromethylsulfonic anhydride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol048624n

Reference yield:

: 32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide

: 777944-33-9
N-(1E)-[(2R)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenyl-2H-pyridin-1-yl]-N-[(S)-2-(1-methoxy-3-methylbutyl)]-benzamidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / NaH / dimethylformamide / 20 h / 20 °C

2.1: Tf₂O / CH₂Cl₂ / 3 h / 20 °C

2.2: 84 percent / CH₂Cl₂ / 4 h / -40 - -10 °C

With trifluoromethylsulfonic anhydride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol048624n