2-(Benzyloxy)-4-bromo-1-methoxybenzene

Base Information

• Chemical Name: 2-(Benzyloxy)-4-bromo-1-methoxybenzene
• CAS No.: 78504-28-6
• Molecular Formula: C14H13BrO2
• Molecular Weight: 293.16
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID40565305
• Nikkaji Number: J1.937.694J
• Wikidata: Q82450337
• Mol file: 78504-28-6.mol

Synonyms:78504-28-6;2-(Benzyloxy)-4-bromoanisole;2-(Benzyloxy)-4-bromo-1-methoxybenzene;4-bromo-1-methoxy-2-phenylmethoxybenzene;MFCD09836381;Benzene, 4-bromo-1-methoxy-2-(phenylmethoxy)-;SCHEMBL2060462;DTXSID40565305;OFFXGGNLPNBCBO-UHFFFAOYSA-N;2-benzyloxy-4-bromo-1-methoxy-benzen;2-Benzyloxy-4-bromo-1-methoxybenzene;3-Benzyloxy-1-bromo-4-methoxybenzene;AKOS005067950;2-benzyloxy-4-bromo-1-methoxy-benzene;AB53368;AS-63706;SY333369;CS-0186436;W15414;A865022

Chemical Property of 2-(Benzyloxy)-4-bromo-1-methoxybenzene

Chemical Property:

• Melting Point: 45-46 °C
• Boiling Point: 358.9±27.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.367±0.06 g/cm3(Predicted)
• LogP: 4.03670
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 292.00989
• Heavy Atom Count: 17
• Complexity: 216

Purity/Quality:

97% ^*data from raw suppliers

2-(Benzyloxy)-4-bromoanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Br)OCC2=CC=CC=C2

Technology Process of 2-(Benzyloxy)-4-bromo-1-methoxybenzene

There total 11 articles about 2-(Benzyloxy)-4-bromo-1-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-bromo-2-methoxyphenol (37942-01-1) + benzyl bromide (100-39-0) → 2-Benzyloxy-4-bromo-1-methoxybenzene (78504-28-6)

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Reflux; Inert atmosphere;

DOI:10.1021/acs.joc.0c00998

Reference yield: 96.0%

→ 2-Benzyloxy-4-bromo-1-methoxybenzene (78504-28-6)

Guidance literature:

Reference yield: 52.0%

5-bromo-2-methoxyphenol (37942-01-1) + benzyl alcohol (100-51-6,185532-71-2) → 2-Benzyloxy-4-bromo-1-methoxybenzene (78504-28-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.08.057

upstream raw materials:

5-bromo-2-methoxyphenol

benzyl chloride

benzyl bromide

5-bromo-2-methoxyphenyl methanesulfonate

Downstream raw materials:

2-(3-benzyloxy-4-methoxyphenylthio)benzoic acid

1-(benzyloxy)-5-bromo-2-methoxy-4-nitrobenzene

(2S,3S,4S,5S)-2-benzyloxymethyl-3,4-dibenzyloxy-5-(3-benzyloxy-4-methoxyphenyl)-N-hydroxy-pyrrolidine

3-(3''-benzyloxy-4''-methoxyphenyl)tricetin 7-benzyl-3',4',5'-trimethyl ether