2-[(2-Hydroxy-3-phenylphenyl)methyl]-6-phenylphenol

Base Information

• Chemical Name: 2-[(2-Hydroxy-3-phenylphenyl)methyl]-6-phenylphenol
• CAS No.: 78576-58-6
• Molecular Formula: C25H20O2
• Molecular Weight: 352.433
• DSSTox Substance ID: DTXSID50504508
• Nikkaji Number: J1.212.286A
• Mol file: 78576-58-6.mol

Synonyms:78576-58-6;SCHEMBL927631;DTXSID50504508;3,3'-Methylenedi([1,1'-biphenyl]-2-ol)

Chemical Property of 2-[(2-Hydroxy-3-phenylphenyl)methyl]-6-phenylphenol

Chemical Property:

• XLogP3: 6.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 352.146329876
• Heavy Atom Count: 27
• Complexity: 398

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC(=C2O)CC3=C(C(=CC=C3)C4=CC=CC=C4)O

Technology Process of 2-[(2-Hydroxy-3-phenylphenyl)methyl]-6-phenylphenol

There total 2 articles about 2-[(2-Hydroxy-3-phenylphenyl)methyl]-6-phenylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Phenylphenol (90-43-7,287950-96-3) → 2,2'-methylene-bis(6-phenylphenol) (78576-58-6)

Guidance literature:

In xylene; at 175 ℃; for 10h;

DOI:10.1055/s-1981-29368

Reference yield: 42.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methylmagnesium bromide (75-16-1) + 2-Phenylphenol (90-43-7,287950-96-3) → 2,2'-methylene-bis(6-phenylphenol) (78576-58-6)

Guidance literature:

methylmagnesium bromide; 2-Phenylphenol; In diethyl ether; at 0 ℃;

formaldehyd; In toluene; for 12h; Further stages.; Heating;

DOI:10.1021/ol016003d

Reference yield: 98.0%

mer,cis-[TaCl3(NMe2)2(NHMe2)] (77071-69-3) + 2,2'-methylene-bis(6-phenylphenol) (78576-58-6) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → [TaCl2(dimethylamido)(dimethylamine)(2,2'-methylenebis(6-phenylphenoxide))]*benzene (375364-95-7)

Guidance literature:

In benzene; byproducts: (Me2NH2)Cl; under N2, standard Schlenk techniques; benzene soln. of ligand added to soln. of Ta complex in benzene; stirred for 24 h; filtered; supernatant collected; layered with pentane; stood for 24 h; ppt. collected; elem. anal.;

DOI:10.1039/b101723n

upstream raw materials:

formaldehyd

2-Phenylphenol

methylmagnesium bromide

Downstream raw materials:

[Ti((OC₆H₃-6-Ph-2)2CH₂)2Cl₂]2

[Ti((OC6H3-6-Ph-2)2CH2)(μ-OPr-i)(OPr-i)]2

[Ta((OC₆H₃-6-Ph-2)2CH₂)2(NMe₂)(Me₂NH)]

[TaCl₂(dimethylamido)(dimethylamine)(2,2'-methylenebis(6-phenylphenoxide))]*benzene