Technology Process of 1,5-Hexadien-3-ol, 3-methyl-1-phenyl-, (3S)-
There total 3 articles about 1,5-Hexadien-3-ol, 3-methyl-1-phenyl-, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
allyl bromide;
With
manganese; chromium(III) bromide; C36H39BN3O3(1-)*H(1+); triethylamine;
at 20 ℃;
for 1h;
Inert atmosphere;
1-Phenylbut-1-en-3-one;
With
chloro-trimethyl-silane;
In
tetrahydrofuran;
at 20 ℃;
for 20h;
Inert atmosphere;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1002/adsc.200900595
- Guidance literature:
-
With
titanium(IV) isopropylate; isopropyl alcohol;
In
dichloromethane;
at 20 ℃;
Overall yield = 85 %; Overall yield = 32.3 mg; enantioselective reaction;
Glovebox;
Inert atmosphere;
DOI:10.1002/chem.201400204
- Guidance literature:
-
B-allyl-1,3,2-dioxaborinane;
With
(S)-2,15-dibromotetraphenylene-1,16-diol;
In
tert-butyl alcohol;
at 25 ℃;
for 0.166667h;
Schlenk technique;
Inert atmosphere;
1-Phenylbut-1-en-3-one;
In
tert-butyl alcohol;
at 25 ℃;
Overall yield = 90 %; Overall yield = 17 mg; enantioselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.joc.8b02475
