(4-Chloro-2-methoxyphenyl)-phenylmethanone

Base Information

Chemical Name:(4-Chloro-2-methoxyphenyl)-phenylmethanone
CAS No.:78589-12-5
Molecular Formula:C14H11ClO2
Molecular Weight:246.68900
Hs Code.:
DSSTox Substance ID:DTXSID50591115
Wikidata:Q82484786

Synonyms:78589-12-5;(4-Chloro-2-methoxyphenyl)-phenylmethanone;SCHEMBL1128828;DTXSID50591115;BIKCMDMCEPKWJD-UHFFFAOYSA-N;AKOS010909418;DS-018518;(4-Chloro-2-methoxyphenyl)(phenyl)methanone

Suppliers and Price of (4-Chloro-2-methoxyphenyl)-phenylmethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-Chloro-2-methoxyphenyl)-phenylmethanone

Chemical Property:

PSA：26.30000
LogP:3.57960
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:246.0447573
Heavy Atom Count:17
Complexity:261

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)Cl)C(=O)C2=CC=CC=C2

Technology Process of (4-Chloro-2-methoxyphenyl)-phenylmethanone

There total 4 articles about (4-Chloro-2-methoxyphenyl)-phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 57479-70-6
2-methoxy-4-chlorobenzoic acid

: 98-80-6
phenylboronic acid

: 78589-12-5
4-chloro-2-methoxybenzophenone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere;
DOI:10.5012/bkcs.2010.31.9.2672

Reference yield: 25.0%

: 2985-80-0
4-chloro-2-hydroxybenzophenone

: 74-88-4
methyl iodide

: 78589-12-5
4-chloro-2-methoxybenzophenone

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 40 ℃; for 21h;
DOI:10.1016/j.tet.2005.09.143

Reference yield:

: 57479-70-6
2-methoxy-4-chlorobenzoic acid

: 78589-12-5
4-chloro-2-methoxybenzophenone

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethylformamide / 2 h / Heating

2: 81 percent / aluminium chloride / 1 h / Heating

3: 25 percent / potassium hydroxide / dimethylsulfoxide / 21 h / 40 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; In dimethyl sulfoxide; 2: Friedel-Crafts reaction;
DOI:10.1016/j.tet.2005.09.143