1-benzoyl-2-methylindole

Base Information

• Chemical Name: 1-benzoyl-2-methylindole
• CAS No.: 78593-46-1
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol file: 78593-46-1.mol

Synonyms:(2-Methyl-indol-1-yl)-phenyl-methanone;1-benzoyl-2-methyl-indole;1-benzoyl-2-methylindole;1-Benzoyl-2-methyl-indol;

Chemical Property of 1-benzoyl-2-methylindole

Chemical Property:

• Melting Point: 74 - 74.5 °C (ethanol)
• PSA: 22.00000
• LogP: 3.63820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzoyl-2-methylindole

There total 26 articles about 1-benzoyl-2-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methyl-1H-indole (95-20-5) + benzoyl chloride (98-88-4) → (2-methyl-1H-indol-3-yl)phenylmethanone (26211-73-4) + (2-methyl-1H-indol-1-yl)(phenyl)methanone (78593-46-1)

Guidance literature:

With MIL-53(Al)(at)SiO₂(at)Fe₃O₄; In dodecane; dichloromethane; at 25 ℃; for 8h; Reagent/catalyst; Temperature; Solvent; Time; Catalytic behavior;

DOI:10.1016/j.cattod.2015.10.003

Reference yield: 95.0%

2-methyl-1H-indole (95-20-5) + benzoyl chloride (98-88-4) → (2-methyl-1H-indol-1-yl)(phenyl)methanone (78593-46-1)

Guidance literature:

2-methyl-1H-indole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

benzoyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol503689r

Reference yield: 93.0%

N-[2-(1-methylethenyl)phenyl]benzamide (106012-41-3) → (2-methyl-1H-indol-1-yl)(phenyl)methanone (78593-46-1)

Guidance literature:

With camphor-10-sulfonic acid; In acetonitrile; at 20 ℃; for 2h; Reagent/catalyst; Temperature; Mechanism;

DOI:10.1021/jacs.8b08350

upstream raw materials:

2-methyl-1H-indole

benzoyl chloride

2-allyl-phenylamine

N-allyl-N-phenylamine

Downstream raw materials:

(1R,2aS,7bS)-3-Benzoyl-2a-methyl-2,2a,3,7b-tetrahydro-1H-cyclobuta[b]indole-1-carboxylic acid methyl ester

(1S,2aS,7bS)-3-Benzoyl-2a-methyl-2,2a,3,7b-tetrahydro-1H-cyclobuta[b]indole-1-carboxylic acid methyl ester

methyl cis-3-benzoyl-2a-methyl-1,2,2a,7b-tetrahydro-3H-cyclobutindole-1-carboxylate

2-methyl-1H-indole