3-BENZOYL-2-METHYLINDOLE

Base Information

• Chemical Name: 3-BENZOYL-2-METHYLINDOLE
• CAS No.: 26211-73-4
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Hs Code.: 2933990090
• Mol file: 26211-73-4.mol

Synonyms:3-Benzoyl-2-methylindole;

Chemical Property of 3-BENZOYL-2-METHYLINDOLE

Chemical Property:

• PSA: 32.86000
• LogP: 3.70730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BENZOYL-2-METHYLINDOLE

There total 43 articles about 3-BENZOYL-2-METHYLINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methyl-1H-indole (95-20-5) + benzoyl chloride (98-88-4) → (2-methyl-1H-indol-3-yl)phenylmethanone (26211-73-4) + (2-methyl-1H-indol-1-yl)(phenyl)methanone (78593-46-1)

Guidance literature:

With MIL-53(Al)(at)SiO₂(at)Fe₃O₄; In dodecane; dichloromethane; at 25 ℃; for 8h; Reagent/catalyst; Temperature; Solvent; Time; Catalytic behavior;

DOI:10.1016/j.cattod.2015.10.003

Reference yield: 89.0%

C15H23BN(1-)*K(1+) + benzoyl chloride (98-88-4) → (2-methyl-1H-indol-3-yl)phenylmethanone (26211-73-4)

Guidance literature:

In tetrahydrofuran; hexane; at -15 ℃; for 24h;

DOI:10.1021/acs.orglett.6b01970

Reference yield: 85.0%

2-methyl-1H-indole (95-20-5) + Benzoylformic acid (611-73-4) → (2-methyl-1H-indol-3-yl)phenylmethanone (26211-73-4)

Guidance literature:

With dipotassium peroxodisulfate; choline acetate; In water; at 40 ℃; for 24h; Reagent/catalyst; Sealed tube;

DOI:10.1039/d1nj05068k

upstream raw materials:

pyridine

benzoyl cyanide

2-methyl-1H-indole

chloroform

Downstream raw materials:

2,3-benzocarbazole

1,3-dibenzoyl-2-methylindole

(3-Benzoyl-2-methyl-indol-1-yl)-(4-chloro-phenyl)-methanone

(3-Benzoyl-2-methyl-indol-1-yl)-(4-methoxy-phenyl)-methanone

Refernces

• 1、 Suzuki, Hitomi,Thiruvikraman, S. V.,Osuka, Atsuhiro. "A Convenient One-Pot Synthesis of 2,3-Disubstituted Indoles". . p. 616 - 617. Retrieved 1984.
• 2、 Hunjan, Mandeep Kaur,Laha, Joydev K.. "K2S2O8activation by glucose at room temperature for the synthesis and functionalization of heterocycles in water". supporting information. p. 8437 - 8440. Retrieved 2021/09/02.
• 3、 Laha, Joydev K.,Kaur Hunjan, Mandeep,Hegde, Shalakha,Gupta, Anjali. "Aroylation of Electron-Rich Pyrroles under Minisci Reaction Conditions". supporting information. p. 1442 - 1447. Retrieved 2020/02/22.