2-Amino-3-(4-chlorobenzoyl)benzeneacetic acid sodium salt

Base Information

• Chemical Name: 2-Amino-3-(4-chlorobenzoyl)benzeneacetic acid sodium salt
• CAS No.: 61941-62-6
• Molecular Formula: C₁₅H₁₁ClNO₃*Na
• Molecular Weight: 0
• Mol file: 61941-62-6.mol

Synonyms:

Chemical Property of 2-Amino-3-(4-chlorobenzoyl)benzeneacetic acid sodium salt

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-3-(4-chlorobenzoyl)benzeneacetic acid sodium salt

There total 6 articles about 2-Amino-3-(4-chlorobenzoyl)benzeneacetic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

7-(p-chlorobenzoyl)-indolin-2-one (61112-01-4) → 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid, sodium salt (61941-62-6)

Guidance literature:

With sodium hydroxide; for 18h; Heating;

DOI:10.1021/jm00377a001

Reference yield:

7-(4-chlorobenzoyl)-3-methylthioindolin-2-one (61085-31-2) → 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid, sodium salt (61941-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / Raney nickel / tetrahydrofuran / 0.17 h

2: 67 percent / 3N aq. NaOH / 18 h / Heating

With sodium hydroxide; nickel; In tetrahydrofuran;

DOI:10.1021/jm00377a001

Reference yield:

2-amino-4'-chlorobenzophenone (2894-51-1) → 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid, sodium salt (61941-62-6)

Guidance literature:

Multi-step reaction with 5 steps

1: tert-butyl hypochlorite / CH₂Cl₂ / 1 h / -70 °C

2: Et₃N / CH₂Cl₂ / -70 - 20 °C

3: 3N aq. HCl / CH₂Cl₂ / 2 h / Heating

4: 93 percent / Raney nickel / tetrahydrofuran / 0.17 h

5: 67 percent / 3N aq. NaOH / 18 h / Heating

With hydrogenchloride; sodium hydroxide; tert-butylhypochlorite; nickel; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00377a001

upstream raw materials:

7-(p-chlorobenzoyl)-indolin-2-one

7-(4-chlorobenzoyl)-3-methylthioindolin-2-one

2-amino-4'-chlorobenzophenone

[2-Amino-3-(4-chloro-benzoyl)-phenyl]-methylsulfanyl-acetic acid ethyl ester

Downstream raw materials:

2-amino-3-(4-chlorobenzoyl)benzeneacetic acid,ethyl ester

3-(4-chlorobenzoyl)-2-<<(trifluoromethyl)carbonyl>amino>benzeneacetic acid, ethyl ester

2-amino-3-[(4-chlorophenyl)hydroxymethyl]benzeneethanol

<2-amino-3-(2-hydroxyethyl)phenyl>(4-chlorophenyl)methanone

Refernces

• 1、 Walsh,Moran,Shamblee,Uwaydah,Welstead Jr.,Sancilio,Dannenburg. "Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues". . p. 1379 - 1388. Retrieved 2007/10/02.