2-Amino-4'-chlorobenzophenone

Base Information

• Chemical Name: 2-Amino-4'-chlorobenzophenone
• CAS No.: 2894-51-1
• Molecular Formula: C13H10ClNO
• Molecular Weight: 231.681
• Hs Code.: 29223990
• European Community (EC) Number: 220-770-3
• DSSTox Substance ID: DTXSID2022200
• Nikkaji Number: J80.590D
• Wikidata: Q72434317
• Mol file: 2894-51-1.mol

Synonyms:2-Amino-4'-chlorobenzophenone;2894-51-1;(2-aminophenyl)(4-chlorophenyl)methanone;(2-aminophenyl)-(4-chlorophenyl)methanone;Methanone, (2-aminophenyl)(4-chlorophenyl)-;EINECS 220-770-3;2-Amino-4'-Chloro Benzophenone;MFCD00025193;(2-Amino-phenyl)-(4-chloro-phenyl)-methanone;2-(4-chlorobenzoyl)aniline;SCHEMBL332626;4'-chloro-2-aminobenzophenone;DTXSID2022200;APHLSUBLNQBFTM-UHFFFAOYSA-;Benzophenone, 2-amino-4'-chloro-;3-(4-Mythylbenzylidene)-d-camphor;AMY15097;CAA89451;AKOS009158907;CS-W005043;DS-15712;SY036440;LS-184931;A1244;FT-0634536;A819683;W-107018;2-Amino-4 inverted exclamation mark -chlorobenzophenone

Chemical Property of 2-Amino-4'-chlorobenzophenone

Chemical Property:

• Melting Point: 103 °C
• Boiling Point: 419.8 °C at 760 mmHg
• PKA: -0.35±0.10(Predicted)
• Flash Point: 207.7 °C
• PSA: 43.09000
• Density: 1.274 g/cm³
• LogP: 3.73440
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Chloroform
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 231.0450916
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

99% ^*data from raw suppliers

(2-Aminophenyl)(4-chlorophenyl)methanone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=CC=C(C=C2)Cl)N
• Uses: 2-Amino-4-chlorobenzophenone is used in the synthesis of antiplasmodial agents.

Technology Process of 2-Amino-4'-chlorobenzophenone

There total 33 articles about 2-Amino-4'-chlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[2-(4-chlorobenzoyl)phenyl]carbamic acid tert-butyl ester → 2-amino-4'-chlorobenzophenone (2894-51-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield: 87.0%

2-((4-chlorophenyl)sulfonamido)benzoic acid (51012-31-8) → 2-amino-4'-chlorobenzophenone (2894-51-1)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In 1,4-dioxane; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/chem.201903816

Reference yield: 85.0%

4-Chlorophenylboronic acid (1679-18-1) + anthranilic acid nitrile (1885-29-6) → 2-amino-4'-chlorobenzophenone (2894-51-1)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water; In 2-methyltetrahydrofuran; at 80 ℃; for 36h; Schlenk technique;

DOI:10.1039/c4ob00978a

upstream raw materials:

3-(4-chlorophenyl)benzo[c]isoxazole

2-(toluene-4-sulfonylamino)-benzoic acid

chlorobenzene

bromochlorobenzene

Downstream raw materials:

2-amino-3-(4-chlorobenzoyl)-α-(phenylthio)benzeneacetamide

7-(4-chlorophenyl)-5,6-dihydrobenzacridine

1-<4-chlor-phenyl>-1-<2-amino-phenyl>-aethanol

2-aminophenyl-α,α-di(p-anisyl) methanol

Refernces

• 1、 -. "THERAPEUTIC CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USING THEM". Paragraph 0325; 0373. . Retrieved 2022/02/15.
• 2、 Fan, Hui,Xu, Shijie,Yang, Fan,Zhang, Xiaoxiang,Zhao, Xuechun. "One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors". supporting information. p. 4555 - 4558. Retrieved 2021/08/30.