2-chloro-N-phenylpyridin-3-amine

Base Information

• Chemical Name: 2-chloro-N-phenylpyridin-3-amine
• CAS No.: 793675-14-6
• Molecular Formula: C11H9ClN2
• Molecular Weight: 204.659
• DSSTox Substance ID: DTXSID10463703
• Nikkaji Number: J2.166.649A
• Mol file: 793675-14-6.mol

Synonyms:2-chloro-N-phenylpyridin-3-amine;793675-14-6;3-Pyridinamine, 2-chloro-N-phenyl-;SCHEMBL22975347;DTXSID10463703;SB77548

Chemical Property of 2-chloro-N-phenylpyridin-3-amine

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 204.0454260
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=C(N=CC=C2)Cl

Technology Process of 2-chloro-N-phenylpyridin-3-amine

There total 11 articles about 2-chloro-N-phenylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-3-aminopyridine (6298-19-7) + cyclohexenone (930-68-7) → N-(2-chloro-3-pyridinyl)-N-phenylamine (793675-14-6)

Guidance literature:

With iodine; toluene-4-sulfonic acid; In dimethyl sulfoxide; at 90 ℃; for 5h; regioselective reaction;

DOI:10.1039/c2cc35801h

Reference yield: 85.0%

3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid phenylamide (830324-73-7) → N-(2-chloro-3-pyridinyl)-N-phenylamine (793675-14-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2005.02.038

Reference yield: 84.0%

2-chloro-3-aminopyridine (6298-19-7) + phenylboronic acid (98-80-6) → N-(2-chloro-3-pyridinyl)-N-phenylamine (793675-14-6)

Guidance literature:

With pyridine; oxygen; In dichloromethane; for 96h; Molecular sieve; Inert atmosphere;

DOI:10.1021/ol300359s

upstream raw materials:

2-chloro-3-iodopyridine

aniline

3-(2-chloro-3-pyridyl)-3,4-dihydro-4-oxo-2-quinazolinecarboxylic acid ethyl ester

3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid phenylamide

Downstream raw materials:

1-phenyl-1H-imidazo[4,5-b]pyridine

N²-1,3-benzodioxol-5-yl-N³-phenylpyridine-2,3-diamine