3-(3-Fluorophenyl)pyridine

Base Information

• Chemical Name: 3-(3-Fluorophenyl)pyridine
• CAS No.: 79412-32-1
• Molecular Formula: C11H8FN
• Molecular Weight: 173.19
• ChEMBL ID: CHEMBL34478
• DSSTox Substance ID: DTXSID80513446
• Wikidata: Q82373273
• Mol file: 79412-32-1.mol

Synonyms:3-(3-fluorophenyl)pyridine;79412-32-1;3-(3-Fluoro-phenyl)-pyridine;CHEMBL34478;SCHEMBL8225016;DTXSID80513446;AKOS006291703

Chemical Property of 3-(3-Fluorophenyl)pyridine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.064077422
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)C2=CN=CC=C2

Technology Process of 3-(3-Fluorophenyl)pyridine

There total 7 articles about 3-(3-Fluorophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-iodopyridine (1120-90-7) + tris(3-flourophenyl)bismuthine (33756-24-0) → 3-(m-fluorophenyl)pyridine (79412-32-1)

Guidance literature:

With potassium phosphate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2014.11.036

Reference yield: 92.0%

3-Bromopyridine (626-55-1,163928-56-1) + 3-fluorophenylboronic acid (768-35-4) → 3-(m-fluorophenyl)pyridine (79412-32-1)

Guidance literature:

With potassium phosphate; {2-[2-(di(2-naphthyloxy)phosphinoxy)-3,5-bis(tert-butyl)phenyl]-4,6-bis(tert-butyl)phenoxy}di(2-naphthyloxy)phosphine; (1,5-cyclo-octadiene) nickel complexes; In toluene; at 80 ℃; for 6h; Product distribution / selectivity;

Reference yield: 51.0%

3-Bromopyridine (626-55-1,163928-56-1) + tris(3-flourophenyl)bismuthine (33756-24-0) → 3-(m-fluorophenyl)pyridine (79412-32-1)

Guidance literature:

With potassium phosphate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201402455

upstream raw materials:

pyridine

meta-fluoroaniline

3-fluorobenzenediazonium tetrafluoroborate

3-Bromopyridine

Downstream raw materials:

3-(3-fluorophenyl)piperidine

3-(3-Fluoro-phenyl)-1-propyl-piperidine