Cyclopent[b]indole-3-acetic acid, 5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)-

Base Information

Chemical Name:Cyclopent[b]indole-3-acetic acid, 5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)-
CAS No.:794535-36-7
Molecular Formula:C22H19ClFNO3
Molecular Weight:399.849
Hs Code.:

Synonyms:

Suppliers and Price of Cyclopent[b]indole-3-acetic acid, 5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopent[b]indole-3-acetic acid, 5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopent[b]indole-3-acetic acid, 5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)-

There total 16 articles about Cyclopent[b]indole-3-acetic acid, 5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 936337-07-4
methyl [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-acetyl-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetate

: 794535-36-7
[5-acetyl-4-(4-chloro-benzyl)-7-fluoro-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1021/jm0603668

Reference yield:

: 393509-22-3
(+/-) 2-(7-fluoro-1,2,3-trihydrocyclopenta[2,3-b]indol-3-yl)acetic acid

: 794535-36-7
[5-acetyl-4-(4-chloro-benzyl)-7-fluoro-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridinium tribromide; pyridine / 0.75 h / -30 - 20 °C

2.1: 117 g / AcOH; Zn / 1 h / 20 °C

3.1: HCl

4.1: NaH / dimethylformamide / 0.33 h / 0 °C

4.2: dimethylformamide / 0.42 h / -50 - 0 °C

5.1: 74.1 g / aq. NaOH / tetrahydrofuran; methanol / 0.25 h / 60 °C

6.1: 42 percent / (S)-(-)-1-(1-naphthyl)ethylamine salt / methanol

7.1: tetrahydrofuran; diethyl ether

8.1: Ph₃As / Pd₂(dba)3 / dimethylformamide / 3.5 h / 90 °C

8.2: 5.5 g / aq. HCl / dimethylformamide / 2 h / 50 °C

9.1: 90 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; triphenyl-arsane; (S)-(-)-1-(1-naphthyl)ethylamine salt; sodium hydride; acetic acid; pyridinium hydrobromide perbromide; zinc; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; 8.1: Stille cross-coupling;
DOI:10.1021/jm0603668

Reference yield:

: 393509-23-4
(5-bromo-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

: 794535-36-7
[5-acetyl-4-(4-chloro-benzyl)-7-fluoro-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: HCl

2.1: NaH / dimethylformamide / 0.33 h / 0 °C

2.2: dimethylformamide / 0.42 h / -50 - 0 °C

3.1: 74.1 g / aq. NaOH / tetrahydrofuran; methanol / 0.25 h / 60 °C

4.1: 42 percent / (S)-(-)-1-(1-naphthyl)ethylamine salt / methanol

5.1: tetrahydrofuran; diethyl ether

6.1: Ph₃As / Pd₂(dba)3 / dimethylformamide / 3.5 h / 90 °C

6.2: 5.5 g / aq. HCl / dimethylformamide / 2 h / 50 °C

7.1: 90 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; sodium hydroxide; triphenyl-arsane; (S)-(-)-1-(1-naphthyl)ethylamine salt; sodium hydride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; 6.1: Stille cross-coupling;
DOI:10.1021/jm0603668