4(1H)-Isoquinolinone, 2,3-dihydro-2-methyl-

Base Information

• Chemical Name: 4(1H)-Isoquinolinone, 2,3-dihydro-2-methyl-
• CAS No.: 79841-13-7
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol file: 79841-13-7.mol

Synonyms:2-methyl-2,3-dihydro-4(1H)-isoquinolone;2-Methyl-2,3-dihydro-1H-isochinolin-4-on;2-methyl-2,3-dihydro-1H-isoquinolin-4-one;2-methyl-2,3-dihydroisoquinolin-4(1H)-one;2-methyl-2,3-dihydro-1H-4-isoquinolone;

Chemical Property of 4(1H)-Isoquinolinone, 2,3-dihydro-2-methyl-

Chemical Property:

• PSA: 20.31000
• LogP: 1.25260

Purity/Quality:

98% ^*data from raw suppliers

2-Methyl-2,3-dihydroisoquinolin-4(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Isoquinolinone, 2,3-dihydro-2-methyl-

There total 1 articles about 4(1H)-Isoquinolinone, 2,3-dihydro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-(chloromethyl)benzoic acid ethyl ester (1531-78-8) → 2-methyl-2,3-dihydroisoquinolin-4(1H)-one (79841-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: sodium; xylene

3: water; hydrochloric acid

With hydrogenchloride; diethyl ether; water; sodium; xylene;

DOI:10.1039/jr9590000599

Reference yield: 97.0%

ethereal hydrogen chloride + 2-methyl-2,3-dihydroisoquinolin-4(1H)-one (79841-13-7) → 4-(2-fluorobenzyl)-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol hydrochloride (86485-15-6)

Guidance literature:

With ammonium chloride;

Reference yield: 89.0%

2-methyl-2,3-dihydroisoquinolin-4(1H)-one (79841-13-7) + Cinnamyl bromide (4392-24-9) → 2-cinnamyl-2-methyl-4-oxo-1,2,3,4-tetrahydroisoquinolinium bromide (79841-14-8)

Guidance literature:

In acetonitrile;

DOI:10.1039/P19810001963

upstream raw materials:

o-(chloromethyl)benzoic acid ethyl ester

Downstream raw materials:

3-benzylidene-2-methyl-2,3-dihydro-1H-isoquinolin-4-one

4-hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline

2-methyl-2,3-dihydro-1H-isoquinolin-4-one-phenylhydrazone

3-(4-dimethylamino-benzylidene)-2-methyl-2,3-dihydro-1H-isoquinolin-4-one