1,2-Dihydro-4,6-diMethyl-2-thioxo-3-pyridinecarboxaMide

Base Information

• Chemical Name: 1,2-Dihydro-4,6-diMethyl-2-thioxo-3-pyridinecarboxaMide
• CAS No.: 79927-21-2
• Molecular Formula: C8H10N2OS
• Molecular Weight: 182.24300
• Mol file: 79927-21-2.mol

Synonyms:1, 2-Dihydro-4, 6-Dimethyl-2-Thioxo-3-Pyridinecarboxamide;1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarboxamide;

Chemical Property of 1,2-Dihydro-4,6-diMethyl-2-thioxo-3-pyridinecarboxaMide

Chemical Property:

• PSA: 90.97000
• LogP: 2.16020

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarboxamide is an impurity of Prasgurel (P701150), a third-generation thienopyridine that is used as an antiplatelet agent.

Technology Process of 1,2-Dihydro-4,6-diMethyl-2-thioxo-3-pyridinecarboxaMide

There total 5 articles about 1,2-Dihydro-4,6-diMethyl-2-thioxo-3-pyridinecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-thiocarbamoylacetamide (72410-06-1) + acetylacetone (123-54-6,81235-32-7) → 4,6-dimethyl-2-mercaptonicotinamide (79927-21-2)

Guidance literature:

With triethylamine; In ethanol; for 24h; Heating;

DOI:10.1055/s-1985-31365

Reference yield: 76.0%

3-cyano-4,6-dimethyl-2-mercaptopyridine (54585-47-6) → 4,6-dimethyl-2-mercaptonicotinic acid amide (79927-21-2)

Guidance literature:

With sulfuric acid; for 3h; Heating;

Reference yield:

2-acetyl-2,5,7-trimethyl-2,3-dihydropyrido<3,2-e>-1,3-thiazin-4-one (97055-43-1) → 4,6-dimethyl-2-mercaptonicotinamide (79927-21-2)

Guidance literature:

With sodium hydroxide; In water; for 1h; Heating;

upstream raw materials:

2-acetyl-2,5,7-trimethyl-2,3-dihydropyrido<3,2-e>-1,3-thiazin-4-one

2-benzoyl-5,7-dimethyl-2,3-dihydropyrido<3,2-e>-1,3-thiazin-4-one

2-thiocarbamoylacetamide

acetylacetone

Downstream raw materials:

2H-2-phenacyl-4,6-dimethylpyrido<3,2-d>isothiazolin-3-one

N₂-ethoxycarbonylmethyl-4,6-dimethylpyrido<3,2-e>isothiazolin-3-one

2H-2-benzyl-4,6-dimethylpyrido<3,2-d>isothiazolin-3-one

2-chloro-4,6-dimethylnicotinonitrile