4-Hydroxy-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: 4-Hydroxy-1H-indole-2-carboxylic acid
• CAS No.: 80129-52-8
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.159
• Hs Code.: 2933990090
• Mol file: 80129-52-8.mol

Synonyms:4-hydroxy-1H-indole-2-carboxylic acid;

Chemical Property of 4-Hydroxy-1H-indole-2-carboxylic acid

Chemical Property:

• Boiling Point: 511.4 °C at 760 mmHg
• PKA: 4.56±0.30(Predicted)
• Flash Point: 263.1 °C
• PSA: 73.32000
• Density: 1.57 g/cm³
• LogP: 1.57170

Purity/Quality:

99% ^*data from raw suppliers

4-hydroxy-1H-indole-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-1H-indole-2-carboxylic acid

There total 4 articles about 4-Hydroxy-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-benzyloxylindole-2-carboxylic acid (39731-09-4) → 4-hydroxy-1H-indole-2-carboxylic acid (80129-52-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 3h; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00108a007

Reference yield:

(Z)-ethyl 2-azido-3-(2-(benzyloxy)phenyl)acrylate (95264-30-5) → 4-hydroxy-1H-indole-2-carboxylic acid (80129-52-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 3 h / Heating

2: 79 percent / 50percent aq. NaOH / ethanol / 0.25 h / Heating

3: 58 percent / H₂ / 10percent Pd/C / ethyl acetate; ethanol / 3 h / 2585.7 Torr / Ambient temperature

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;

DOI:10.1021/jm00108a007

Reference yield:

4-benzyloxy-1H-indole-2-carboxylic acid ethyl ester (27737-55-9) → 4-hydroxy-1H-indole-2-carboxylic acid (80129-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / 50percent aq. NaOH / ethanol / 0.25 h / Heating

2: 58 percent / H₂ / 10percent Pd/C / ethyl acetate; ethanol / 3 h / 2585.7 Torr / Ambient temperature

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00108a007

upstream raw materials:

4-benzyloxylindole-2-carboxylic acid

(Z)-ethyl 2-azido-3-(2-(benzyloxy)phenyl)acrylate

4-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

2-(phenylmethoxy)benzaldehyde

Refernces