N-(2-bromophenyl)-2-cyanoacetamide

Base Information

• Chemical Name: N-(2-bromophenyl)-2-cyanoacetamide
• CAS No.: 80277-87-8
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.071
• Hs Code.: 2926909090
• Mol file: 80277-87-8.mol

Synonyms:N-(2-BROMOPHENYL)-2-CYANOACETAMIDE;

Chemical Property of N-(2-bromophenyl)-2-cyanoacetamide

Chemical Property:

• PSA: 52.89000
• LogP: 2.37428

Purity/Quality:

N-(2-BROMOPHENYL)-2-CYANOACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-bromophenyl)-2-cyanoacetamide

There total 2 articles about N-(2-bromophenyl)-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cyanoacetic acid (372-09-8) + 2-bromoaniline (615-36-1) → 2-cyano-N-[2-(bromo)phenyl]acetamide (80277-87-8)

Guidance literature:

cyanoacetic acid; With phosphorus pentachloride; In dichloromethane; for 0.5h; Reflux;

2-bromoaniline; In dichloromethane; for 2h; Reflux;

DOI:10.1021/jm3002845

Reference yield:

ethyl 2-cyanoacetate (105-56-6) + 2-bromoaniline (615-36-1) → 2-cyano-N-[2-(bromo)phenyl]acetamide (80277-87-8)

Guidance literature:

With 1H-imidazole; In ethanol; at 200 ℃;

DOI:10.1016/j.bmcl.2008.12.078

Reference yield: 77.0%

2-cyano-N-[2-(bromo)phenyl]acetamide (80277-87-8) → 3-amino-3-(hydroxyimino)-N-[2-(bromo)phenyl]propanamide (1094268-10-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In methanol; water; for 2h; Reflux;

DOI:10.1021/jm3002845

upstream raw materials:

ethyl 2-cyanoacetate

2-bromoaniline

cyanoacetic acid

Downstream raw materials:

C₉H₆BrN₃O₂

3-amino-3-(hydroxyimino)-N-[2-(bromo)phenyl]propanamide

Refernces

• 1、 Kiselyov, Alexander S.,Semenova, Marina,Semenov, Victor V.. "3,4-Disubstituted isothiazoles: Novel potent inhibitors of VEGF receptors 1 and 2". scheme or table. p. 1195 - 1198. Retrieved 2009/08/07.