Imidazo[1,2-c]pyrimidine-2-carboxylic acid, 5,7-dimethyl-

Base Information

• Chemical Name: Imidazo[1,2-c]pyrimidine-2-carboxylic acid, 5,7-dimethyl-
• CAS No.: 80353-96-4
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.18700

Synonyms:5,7-Dimethylimidazo[1,2-c]pyrimidine-2-carboxylic acid;5,7-Dimethyl-imidazo[1,2-c]pyrimidine-2-carboxylic acid;

Chemical Property of Imidazo[1,2-c]pyrimidine-2-carboxylic acid, 5,7-dimethyl-

Chemical Property:

• PSA: 67.49000
• LogP: 1.04430

Purity/Quality:

97% ^*data from raw suppliers

5,7-dimethyl-Imidazo[1,2-c]pyrimidine-2-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-c]pyrimidine-2-carboxylic acid, 5,7-dimethyl-

There total 2 articles about Imidazo[1,2-c]pyrimidine-2-carboxylic acid, 5,7-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethyl 5,7-dimethylimidazo<1,2-c>pyrimidine-2-carboxylate (76075-36-0) → 5,7-dimethylimidazo<1,2-c>pyrimidine-2-carboxylic acid (80353-96-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1h; Heating;

Reference yield:

4-amino-2,6-dimethylpyrimidine (461-98-3) → 5,7-dimethylimidazo<1,2-c>pyrimidine-2-carboxylic acid (80353-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 20 °C / Reflux

2: sodium hydroxide; ethanol / 1.5 h / 0 - 20 °C

With ethanol; sodium hydroxide; In ethanol;

Reference yield:

quinoclamine (2797-51-5) + (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile (1297540-77-2) + 5,7-dimethylimidazo<1,2-c>pyrimidine-2-carboxylic acid (80353-96-4) → (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5,7-dimethylimidazo[1,2-c]pyrimidine-2-carboxamide (1403332-64-8)

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

ethyl 5,7-dimethylimidazo<1,2-c>pyrimidine-2-carboxylate

4-amino-2,6-dimethylpyrimidine

Downstream raw materials:

(S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5,7-dimethylimidazo[1,2-c]pyrimidine-2-carboxamide

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