6-(4-Methoxyphenyl)hex-5-enoic acid

Base Information

Chemical Name:6-(4-Methoxyphenyl)hex-5-enoic acid
CAS No.:81077-29-4
Molecular Formula:C13H16O3
Molecular Weight:220.268
Hs Code.:
DSSTox Substance ID:DTXSID70709912

Synonyms:6-(4-Methoxyphenyl)hex-5-enoic acid;81077-29-4;SCHEMBL8862104;DTXSID70709912

Suppliers and Price of 6-(4-Methoxyphenyl)hex-5-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-(4-Methoxyphenyl)hex-5-enoic acid

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:220.109944368
Heavy Atom Count:16
Complexity:227

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C=CCCCC(=O)O

Technology Process of 6-(4-Methoxyphenyl)hex-5-enoic acid

There total 5 articles about 6-(4-Methoxyphenyl)hex-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 123-11-5
4-methoxy-benzaldehyde

: 81077-29-4
(E)-6-(4-methoxyphenyl)pent-5-enoic acid

Guidance literature:: (4-carboxybutyl)triphenylphosphonium bromide; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

4-methoxy-benzaldehyde; In tetrahydrofuran; hexane; for 2h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2020.131740

Reference yield:

: 42186-61-8
5-(Triphenyl-λ⁵-phosphanylidene)-pentanoic acid anion

: 123-11-5
4-methoxy-benzaldehyde

: 81077-29-4
(E)-6-(4-methoxyphenyl)pent-5-enoic acid

: 81077-24-9
cis 6-(p-methoxyphenyl)-5-hexenoic acid

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(01)82099-2

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 81077-29-4
(E)-6-(4-methoxyphenyl)pent-5-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

2: lithium hexamethyldisilazide / tetrahydrofuran / 25 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)82099-2